DESI-based imaging mass spectrometry in forensic science and clinical diagnosis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In the decades following the successful introduction of two soft ionization methods, viz., matrix-assisted laser desorption ionization (MALDI) and electrospray ionization ESI, several promising and practical techniques have been developed to perform ionization under ambient conditions. Desorption electrospray ionization (DESI) is one of the most popular ambient ionization methods and has been implemented in numerous fields. Imaging mass spectrometry (IMS) coupled with DESI is among the most successful of these applications, particularly in the fields of forensic science and molecular biology. Unlike MALDI based IMS which involves a matrix application process, sample preparation for DESI-IMS is a simple and minimal procedure that can be potentially performed by nonexperts, including hospital laboratory technicians. Moreover, DESI enables surface analysis of various materials under ambient conditions. Skin, glass, rubber, and even cotton can be analyzed using this ionization technique. Thus, DESI is versatile in situations typically encountered in forensic analysis. Rapid and facile DESI-based chemical detection and IMS are practical methods for forensic testing and clinical diagnosis.

Original languageEnglish
Title of host publicationAmbient Ionization Mass Spectrometry in Life Sciences
Subtitle of host publicationPrinciples and Applications
PublisherElsevier
Pages107-118
Number of pages12
ISBN (Electronic)9780128172209
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • Clinical diagnosis
  • Desorption electrospray ionization (DESI)
  • Forensic science
  • Imaging mass spectrometry (IMS)
  • Reactive DESI

ASJC Scopus subject areas

  • Chemistry(all)

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