TY - JOUR
T1 - Design and synthesis of 1-thia-3,8-diyn-5-ene systems with DNA-cleaving properties related to the neocarzinostatin chromophore
AU - Toshima, Kazunobu
AU - Ohta, Kazumi
AU - Ohashi, Aya
AU - Ohtsuka, Atsuo
AU - Nakata, Masaya
AU - Tatsuta, Kuniaki
PY - 1992/12/1
Y1 - 1992/12/1
N2 - 1-Thia-3,8-diyn-5-ene compounds 5-10, which are derivatives of the parent compound 1 are synthesized in a short step with high stability; these compounds show DNA-cleaving activity under basic conditions in the absence of any additives.
AB - 1-Thia-3,8-diyn-5-ene compounds 5-10, which are derivatives of the parent compound 1 are synthesized in a short step with high stability; these compounds show DNA-cleaving activity under basic conditions in the absence of any additives.
UR - http://www.scopus.com/inward/record.url?scp=0026787045&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026787045&partnerID=8YFLogxK
U2 - 10.1039/C39920001306
DO - 10.1039/C39920001306
M3 - Article
AN - SCOPUS:0026787045
SN - 1359-7345
SP - 1306
EP - 1308
JO - Chemical Communications
JF - Chemical Communications
IS - 18
ER -