Design and synthesis of a novel fluorescence probe for Zn2+ based on the spirolactam ring-opening process of rhodamine derivatives

Hiromi Sasaki, Kenjiro Hanaoka, Yasuteru Urano, Takuya Terai, Tetsuo Nagano

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

The spirolactam ring-opening process of rhodamine derivative is one of the most useful mechanisms for controlling fluorescence properties. However, the open/closed equilibrium reaction of rhodamine spirolactam has not been well characterized. Therefore, we examined the relationship between the spirolactam ring-opening process of rhodamine derivatives and the structure of the xanthene moiety. Based on the results of this investigation, we selected a candidate xanthene moiety for a Zn2+ sensor, and successfully developed a new fluorescence probe for Zn2+.

Original languageEnglish
Pages (from-to)1072-1078
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume19
Issue number3
DOIs
Publication statusPublished - 2011 Feb 1
Externally publishedYes

Keywords

  • Fluorescence
  • Rhodamine
  • Sensors
  • Zinc ion

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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