Design and synthesis of a novel magnetic resonance imaging contrast agent for selective sensing of zinc ion

Kenjiro Hanaoka; Kazuya Kikuchi; Yasuteru Urano; Michiko Narazaki; Takashi Yokawa; Shigeru Sakamoto; Kentaro Yamaguchi; Tetsuo Nagano

doi:10.1016/S1074-5521(02)00216-8

Design and synthesis of a novel magnetic resonance imaging contrast agent for selective sensing of zinc ion

Kenjiro Hanaoka, Kazuya Kikuchi, Yasuteru Urano, Michiko Narazaki, Takashi Yokawa, Shigeru Sakamoto, Kentaro Yamaguchi, Tetsuo Nagano

Research output: Contribution to journal › Article › peer-review

95 Citations (Scopus)

Abstract

A series of new diethylenetriaminepentaacetic acid (DTPA)-bisamide chelators has been prepared and characterized for application as zinc sensors. We have designed and synthesized (GdL^a)^2-, which contains a DTPA-bisamide moiety. The R₁ relaxivity of (GdL^a)^2- solution decreased monotonically on the addition of Zn²⁺. Moreover, (GdL^a)^2- showed high selectivity for Zn²⁺ against Ca²⁺ and Mg²⁺. We also measured the UV-visible spectra and the coldspray ionization (CSI) MS spectra and concluded that the 1-to-1 Zn²⁺ complex of (GdL^a)^2- is stable at higher concentrations of Zn²⁺. These complexes should provide the basis for creating a superior Zn²⁺-sensitive MRI contrast agent and are excellent candidates for incorporation into sensors designed for selective detection of Zn²⁺ in biological applications.

Original language	English
Pages (from-to)	1027-1032
Number of pages	6
Journal	Chemistry and Biology
Volume	9
Issue number	9
DOIs	https://doi.org/10.1016/S1074-5521(02)00216-8
Publication status	Published - 2002 Sep
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/S1074-5521(02)00216-8

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Design and synthesis of a novel magnetic resonance imaging contrast agent for selective sensing of zinc ion. / Hanaoka, Kenjiro; Kikuchi, Kazuya; Urano, Yasuteru; Narazaki, Michiko; Yokawa, Takashi; Sakamoto, Shigeru; Yamaguchi, Kentaro; Nagano, Tetsuo.

In: Chemistry and Biology, Vol. 9, No. 9, 09.2002, p. 1027-1032.

Research output: Contribution to journal › Article › peer-review

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abstract = "A series of new diethylenetriaminepentaacetic acid (DTPA)-bisamide chelators has been prepared and characterized for application as zinc sensors. We have designed and synthesized (GdLa)2-, which contains a DTPA-bisamide moiety. The R1 relaxivity of (GdLa)2- solution decreased monotonically on the addition of Zn2+. Moreover, (GdLa)2- showed high selectivity for Zn2+ against Ca2+ and Mg2+. We also measured the UV-visible spectra and the coldspray ionization (CSI) MS spectra and concluded that the 1-to-1 Zn2+ complex of (GdLa)2- is stable at higher concentrations of Zn2+. These complexes should provide the basis for creating a superior Zn2+-sensitive MRI contrast agent and are excellent candidates for incorporation into sensors designed for selective detection of Zn2+ in biological applications.",

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AU - Urano, Yasuteru

AU - Narazaki, Michiko

AU - Yokawa, Takashi

AU - Sakamoto, Shigeru

AU - Yamaguchi, Kentaro

AU - Nagano, Tetsuo

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AB - A series of new diethylenetriaminepentaacetic acid (DTPA)-bisamide chelators has been prepared and characterized for application as zinc sensors. We have designed and synthesized (GdLa)2-, which contains a DTPA-bisamide moiety. The R1 relaxivity of (GdLa)2- solution decreased monotonically on the addition of Zn2+. Moreover, (GdLa)2- showed high selectivity for Zn2+ against Ca2+ and Mg2+. We also measured the UV-visible spectra and the coldspray ionization (CSI) MS spectra and concluded that the 1-to-1 Zn2+ complex of (GdLa)2- is stable at higher concentrations of Zn2+. These complexes should provide the basis for creating a superior Zn2+-sensitive MRI contrast agent and are excellent candidates for incorporation into sensors designed for selective detection of Zn2+ in biological applications.

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Design and synthesis of a novel magnetic resonance imaging contrast agent for selective sensing of zinc ion

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