Abstract
A series of new diethylenetriaminepentaacetic acid (DTPA)-bisamide chelators has been prepared and characterized for application as zinc sensors. We have designed and synthesized (GdLa)2-, which contains a DTPA-bisamide moiety. The R1 relaxivity of (GdLa)2- solution decreased monotonically on the addition of Zn2+. Moreover, (GdLa)2- showed high selectivity for Zn2+ against Ca2+ and Mg2+. We also measured the UV-visible spectra and the coldspray ionization (CSI) MS spectra and concluded that the 1-to-1 Zn2+ complex of (GdLa)2- is stable at higher concentrations of Zn2+. These complexes should provide the basis for creating a superior Zn2+-sensitive MRI contrast agent and are excellent candidates for incorporation into sensors designed for selective detection of Zn2+ in biological applications.
Original language | English |
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Pages (from-to) | 1027-1032 |
Number of pages | 6 |
Journal | Chemistry and Biology |
Volume | 9 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2002 Sep |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Drug Discovery
- Clinical Biochemistry