Abstract
(Equation Presented) We describe the design and synthesis of latex particles attached to an FR225659 derivative to identify its receptor proteins. Two key building blocks were prepared by two-step degradation of FR225659 under basic conditions. The designed ligand showed an acceptable level of biological activity to make it of potential value for use in affinity-supported receptor identification. Affinity purification of FR225659-binding proteins using the latex nanoparticles provided three candidate receptor peptides for the biological activity.
| Original language | English |
|---|---|
| Pages (from-to) | 2477-2480 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 6 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - 2004 Jul 8 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Zenkoh, T., Hatori, H., Tanaka, H., Hasegawa, M., Hatakeyama, M., Kabe, Y., Setoi, H., Kawaguchi, H., Handa, H., & Takahashi, T. (2004). Design and synthesis of a solid-supported FR225659 derivative for its receptor screening. Organic Letters, 6(14), 2477-2480. https://doi.org/10.1021/ol049100q