Abstract
(Equation Presented) We describe the design and synthesis of latex particles attached to an FR225659 derivative to identify its receptor proteins. Two key building blocks were prepared by two-step degradation of FR225659 under basic conditions. The designed ligand showed an acceptable level of biological activity to make it of potential value for use in affinity-supported receptor identification. Affinity purification of FR225659-binding proteins using the latex nanoparticles provided three candidate receptor peptides for the biological activity.
Original language | English |
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Pages (from-to) | 2477-2480 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 6 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2004 Jul 8 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry