Design and synthesis of a solid-supported FR225659 derivative for its receptor screening

Tatsuya Zenkoh, Hidetaka Hatori, Hiroshi Tanaka, Makoto Hasegawa, Mamoru Hatakeyama, Yasuaki Kabe, Hiroyuki Setoi, Haruma Kawaguchi, Hiroshi Handa, Takashi Takahashi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

(Equation Presented) We describe the design and synthesis of latex particles attached to an FR225659 derivative to identify its receptor proteins. Two key building blocks were prepared by two-step degradation of FR225659 under basic conditions. The designed ligand showed an acceptable level of biological activity to make it of potential value for use in affinity-supported receptor identification. Affinity purification of FR225659-binding proteins using the latex nanoparticles provided three candidate receptor peptides for the biological activity.

Original languageEnglish
Pages (from-to)2477-2480
Number of pages4
JournalOrganic Letters
Volume6
Issue number14
DOIs
Publication statusPublished - 2004 Jul 8
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Zenkoh, T., Hatori, H., Tanaka, H., Hasegawa, M., Hatakeyama, M., Kabe, Y., Setoi, H., Kawaguchi, H., Handa, H., & Takahashi, T. (2004). Design and synthesis of a solid-supported FR225659 derivative for its receptor screening. Organic Letters, 6(14), 2477-2480. https://doi.org/10.1021/ol049100q