Design and synthesis of a solid-supported FR225659 derivative for its receptor screening

Tatsuya Zenkoh; Hidetaka Hatori; Hiroshi Tanaka; Makoto Hasegawa; Mamoru Hatakeyama; Yasuaki Kabe; Hiroyuki Setoi; Haruma Kawaguchi; Hiroshi Handa; Takashi Takahashi

doi:10.1021/ol049100q

Design and synthesis of a solid-supported FR225659 derivative for its receptor screening

Tatsuya Zenkoh, Hidetaka Hatori, Hiroshi Tanaka, Makoto Hasegawa, Mamoru Hatakeyama, Yasuaki Kabe, Hiroyuki Setoi, Haruma Kawaguchi, Hiroshi Handa, Takashi Takahashi

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

(Equation Presented) We describe the design and synthesis of latex particles attached to an FR225659 derivative to identify its receptor proteins. Two key building blocks were prepared by two-step degradation of FR225659 under basic conditions. The designed ligand showed an acceptable level of biological activity to make it of potential value for use in affinity-supported receptor identification. Affinity purification of FR225659-binding proteins using the latex nanoparticles provided three candidate receptor peptides for the biological activity.

Original language	English
Pages (from-to)	2477-2480
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	14
DOIs	https://doi.org/10.1021/ol049100q
Publication status	Published - 2004 Jul 8
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol049100q

Cite this

@article{4ffb7b00684248efa9e01b8fea3e5e09,

title = "Design and synthesis of a solid-supported FR225659 derivative for its receptor screening",

abstract = "(Equation Presented) We describe the design and synthesis of latex particles attached to an FR225659 derivative to identify its receptor proteins. Two key building blocks were prepared by two-step degradation of FR225659 under basic conditions. The designed ligand showed an acceptable level of biological activity to make it of potential value for use in affinity-supported receptor identification. Affinity purification of FR225659-binding proteins using the latex nanoparticles provided three candidate receptor peptides for the biological activity.",

author = "Tatsuya Zenkoh and Hidetaka Hatori and Hiroshi Tanaka and Makoto Hasegawa and Mamoru Hatakeyama and Yasuaki Kabe and Hiroyuki Setoi and Haruma Kawaguchi and Hiroshi Handa and Takashi Takahashi",

year = "2004",

month = jul,

day = "8",

doi = "10.1021/ol049100q",

language = "English",

volume = "6",

pages = "2477--2480",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "14",

}

TY - JOUR

T1 - Design and synthesis of a solid-supported FR225659 derivative for its receptor screening

AU - Zenkoh, Tatsuya

AU - Hatori, Hidetaka

AU - Tanaka, Hiroshi

AU - Hasegawa, Makoto

AU - Hatakeyama, Mamoru

AU - Kabe, Yasuaki

AU - Setoi, Hiroyuki

AU - Kawaguchi, Haruma

AU - Handa, Hiroshi

AU - Takahashi, Takashi

PY - 2004/7/8

Y1 - 2004/7/8

N2 - (Equation Presented) We describe the design and synthesis of latex particles attached to an FR225659 derivative to identify its receptor proteins. Two key building blocks were prepared by two-step degradation of FR225659 under basic conditions. The designed ligand showed an acceptable level of biological activity to make it of potential value for use in affinity-supported receptor identification. Affinity purification of FR225659-binding proteins using the latex nanoparticles provided three candidate receptor peptides for the biological activity.

AB - (Equation Presented) We describe the design and synthesis of latex particles attached to an FR225659 derivative to identify its receptor proteins. Two key building blocks were prepared by two-step degradation of FR225659 under basic conditions. The designed ligand showed an acceptable level of biological activity to make it of potential value for use in affinity-supported receptor identification. Affinity purification of FR225659-binding proteins using the latex nanoparticles provided three candidate receptor peptides for the biological activity.

UR - http://www.scopus.com/inward/record.url?scp=3242699908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242699908&partnerID=8YFLogxK

U2 - 10.1021/ol049100q

DO - 10.1021/ol049100q

M3 - Article

C2 - 15228308

AN - SCOPUS:3242699908

VL - 6

SP - 2477

EP - 2480

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 14

ER -

Design and synthesis of a solid-supported FR225659 derivative for its receptor screening

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this