Design and synthesis of chiral hybrid spiro (isoxazole-isoxazoline) ligands

Priti S. Koranne; Tetsuya Tsujihara; Midori A. Arai; Gan B. Bajracharya; Takeyuki Suzuki; Kiyotaka Onitsuka; Hiroaki Sasai

doi:10.1016/j.tetasy.2007.04.010

Design and synthesis of chiral hybrid spiro (isoxazole-isoxazoline) ligands

Priti S. Koranne, Tetsuya Tsujihara, Midori A. Arai, Gan B. Bajracharya, Takeyuki Suzuki, Kiyotaka Onitsuka, Hiroaki Sasai

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Novel chiral hybrid ligands containing an unsymmetrical spiro[4.5]decane skeleton with isoxazole and isoxazoline as the two coordinating units have been synthesized. Pd complexes of these ligands were found to be effective in activating olefins towards enantioselective tandem cyclization of a dialkenyl alcohol, providing the cyclized products in up to 97% ee.

Original language	English
Pages (from-to)	919-923
Number of pages	5
Journal	Tetrahedron Asymmetry
Volume	18
Issue number	8
DOIs	https://doi.org/10.1016/j.tetasy.2007.04.010
Publication status	Published - 2007 May 16
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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abstract = "Novel chiral hybrid ligands containing an unsymmetrical spiro[4.5]decane skeleton with isoxazole and isoxazoline as the two coordinating units have been synthesized. Pd complexes of these ligands were found to be effective in activating olefins towards enantioselective tandem cyclization of a dialkenyl alcohol, providing the cyclized products in up to 97% ee.",

author = "Koranne, {Priti S.} and Tetsuya Tsujihara and Arai, {Midori A.} and Bajracharya, {Gan B.} and Takeyuki Suzuki and Kiyotaka Onitsuka and Hiroaki Sasai",

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AU - Koranne, Priti S.

AU - Tsujihara, Tetsuya

AU - Arai, Midori A.

AU - Bajracharya, Gan B.

AU - Suzuki, Takeyuki

AU - Onitsuka, Kiyotaka

AU - Sasai, Hiroaki

PY - 2007/5/16

Y1 - 2007/5/16

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AB - Novel chiral hybrid ligands containing an unsymmetrical spiro[4.5]decane skeleton with isoxazole and isoxazoline as the two coordinating units have been synthesized. Pd complexes of these ligands were found to be effective in activating olefins towards enantioselective tandem cyclization of a dialkenyl alcohol, providing the cyclized products in up to 97% ee.

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