We designed and synthesized conformationally restricted analogues and regioisomers of the nonsteroidal anti-inflammatory drug indomethacin. Evaluation of the inhibitory effects of these compounds on COX, P-glycoprotein, and multidrug resistance indicated that NSAIDS modulation of multidrug-resistant P-glycoprotein and multidrug-resistant protein-1 is not associated with COX-1 and COX-2 inhibitory activities.
|Number of pages||12|
|Journal||Journal of Medicinal Chemistry|
|Publication status||Published - 2012 Sept 27|
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery