Design and synthesis of lithium ionophores for an ion-selective electrode by chemical modification of natural carboxylic polyether antibiotic monensin

Koji Tohda, Koji Suzuki, Nobutaka Kosuge, Kazuhiko Watanabe, Hitoshi Nagashima, Hidenari Inoue, Tsuneo Shirai

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Ion-selective electrodes were prepared with 12 kinds of monensin derivatives obtained by chemical modification of natural antibiotic monensin, and the relationship between the chemical structures of the derivatives and the ion selectivities of those electrodes was investigated for designing Li+-selective ionophores. Lactonization of monensin and subsequent acylation of its tertiary hydroxyl group are effective for obtaining highly Li+-selective ionophores. Of all the monensin derivatives synthesized, macrocyclic monensin monoisobutyrate proved to have the highest Li+ selectivity. The selectivity coefficient of Li+ to Na+ (log KLINapot) was -1.8 in the poly(vinyl chloride) (PVC) matrix membrane electrode, which was prepared by using the macrocyclic monensin derivative and dibenzyl ether (DBE) as the membrane solvent.

Original languageEnglish
Pages (from-to)936-942
Number of pages7
JournalAnalytical Chemistry
Volume62
Issue number9
Publication statusPublished - 1990 May 1

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Monensin
Polyethers
Ionophores
Chemical modification
Lithium
Anti-Bacterial Agents
Derivatives
Membranes
Vinyl Chloride
Acylation
Electrodes
Polyvinyl Chloride
Hydroxyl Radical
Ion-Selective Electrodes
Ions

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Tohda, K., Suzuki, K., Kosuge, N., Watanabe, K., Nagashima, H., Inoue, H., & Shirai, T. (1990). Design and synthesis of lithium ionophores for an ion-selective electrode by chemical modification of natural carboxylic polyether antibiotic monensin. Analytical Chemistry, 62(9), 936-942.

Design and synthesis of lithium ionophores for an ion-selective electrode by chemical modification of natural carboxylic polyether antibiotic monensin. / Tohda, Koji; Suzuki, Koji; Kosuge, Nobutaka; Watanabe, Kazuhiko; Nagashima, Hitoshi; Inoue, Hidenari; Shirai, Tsuneo.

In: Analytical Chemistry, Vol. 62, No. 9, 01.05.1990, p. 936-942.

Research output: Contribution to journalArticle

Tohda, K, Suzuki, K, Kosuge, N, Watanabe, K, Nagashima, H, Inoue, H & Shirai, T 1990, 'Design and synthesis of lithium ionophores for an ion-selective electrode by chemical modification of natural carboxylic polyether antibiotic monensin', Analytical Chemistry, vol. 62, no. 9, pp. 936-942.
Tohda, Koji ; Suzuki, Koji ; Kosuge, Nobutaka ; Watanabe, Kazuhiko ; Nagashima, Hitoshi ; Inoue, Hidenari ; Shirai, Tsuneo. / Design and synthesis of lithium ionophores for an ion-selective electrode by chemical modification of natural carboxylic polyether antibiotic monensin. In: Analytical Chemistry. 1990 ; Vol. 62, No. 9. pp. 936-942.
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