Design and synthesis of sodium ion-selective ionophores based on 16-crown-5 derivatives for an ion-selective electrode

Koji Suzuki, Kazunari Sato, Hideaki Hisamoto, Dwi Siswanta, Kazuo Hayashi, Noriko Kasahara, Kazuhiko Watanabe, Noriko Yamamoto, Hideshi Sasakura

Research output: Contribution to journalArticle

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Abstract

To develop an ionophore that is highly selective for sodium for use in an ion-selective electrode, we propose a model based on 16-crown-5 which has a cavity just the size of Na+ and has a "block" subunit to prevent complex formation with ions larger than Na+. Based on this molecular model, eight kinds of 16-crown-5 derivatives have been synthesized, and their structural ion selectivity has been evaluated in detail. The 16-crown-5 derivatives having two bulky "block" subunits showed high Na+ selectivity relative to K+. In particular, the derivative with two decalino subunits (DD16C5) exhibited the highest Na+ selectivity of all the ionophores examined. When a phosphate ester-type membrane plasticizer, tris(ethyl-hexyl) phosphate, was used as the membrane solvent for the ion-sensing membrane based on pory(vinyl chloride), the electrode using DD16C5 exhibited a Na+ selectivity of over 1000 times relative to alkali metal and alkaline earth metal ions, including K+, which is the most serious interferant The evaluation of the relationship between the ionophore chemical structures and the ion-selective features contributes to the host-guest chemistry to give a highly selective ionophore for an alkali metal ion.

Original languageEnglish
Pages (from-to)208-215
Number of pages8
JournalAnalytical Chemistry
Volume68
Issue number1
Publication statusPublished - 1996

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Ionophores
Sodium
Ions
Alkali Metals
Derivatives
Membranes
Metal ions
Alkaline Earth Metals
Phosphates
Vinyl Chloride
Plasticizers
Heavy ions
Esters
Electrodes
Ion-Selective Electrodes

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Suzuki, K., Sato, K., Hisamoto, H., Siswanta, D., Hayashi, K., Kasahara, N., ... Sasakura, H. (1996). Design and synthesis of sodium ion-selective ionophores based on 16-crown-5 derivatives for an ion-selective electrode. Analytical Chemistry, 68(1), 208-215.

Design and synthesis of sodium ion-selective ionophores based on 16-crown-5 derivatives for an ion-selective electrode. / Suzuki, Koji; Sato, Kazunari; Hisamoto, Hideaki; Siswanta, Dwi; Hayashi, Kazuo; Kasahara, Noriko; Watanabe, Kazuhiko; Yamamoto, Noriko; Sasakura, Hideshi.

In: Analytical Chemistry, Vol. 68, No. 1, 1996, p. 208-215.

Research output: Contribution to journalArticle

Suzuki, K, Sato, K, Hisamoto, H, Siswanta, D, Hayashi, K, Kasahara, N, Watanabe, K, Yamamoto, N & Sasakura, H 1996, 'Design and synthesis of sodium ion-selective ionophores based on 16-crown-5 derivatives for an ion-selective electrode', Analytical Chemistry, vol. 68, no. 1, pp. 208-215.
Suzuki K, Sato K, Hisamoto H, Siswanta D, Hayashi K, Kasahara N et al. Design and synthesis of sodium ion-selective ionophores based on 16-crown-5 derivatives for an ion-selective electrode. Analytical Chemistry. 1996;68(1):208-215.
Suzuki, Koji ; Sato, Kazunari ; Hisamoto, Hideaki ; Siswanta, Dwi ; Hayashi, Kazuo ; Kasahara, Noriko ; Watanabe, Kazuhiko ; Yamamoto, Noriko ; Sasakura, Hideshi. / Design and synthesis of sodium ion-selective ionophores based on 16-crown-5 derivatives for an ion-selective electrode. In: Analytical Chemistry. 1996 ; Vol. 68, No. 1. pp. 208-215.
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