TY - JOUR
T1 - Design, cycloaromatization and guanine-selective DNA cleavage of novel enediynes
AU - Toshima, Kazunobu
AU - Ohta, Kazumi
AU - Kano, Takaaki
AU - Nakamura, Takatsugu
AU - Nakata, Masaya
AU - Matsumura, Shuichi
PY - 1994/12/1
Y1 - 1994/12/1
N2 - The novel enediynes 7-9 are synthesized from xylitol 1 via the keto-enediyne 2; they are aromatized by 1,8-diazabicyclo[5.4.0]undec-7-ene in cyclohexa-1,4-diene-benzene through a radical pathway and by diethylamine in Me2SO-tris-HCl, pH 8.5 buffer through a polar pathway, and exhibit gunine-selective DNA cleavage under basic conditions with no additive.
AB - The novel enediynes 7-9 are synthesized from xylitol 1 via the keto-enediyne 2; they are aromatized by 1,8-diazabicyclo[5.4.0]undec-7-ene in cyclohexa-1,4-diene-benzene through a radical pathway and by diethylamine in Me2SO-tris-HCl, pH 8.5 buffer through a polar pathway, and exhibit gunine-selective DNA cleavage under basic conditions with no additive.
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U2 - 10.1039/C39940002295
DO - 10.1039/C39940002295
M3 - Article
AN - SCOPUS:0027937343
SN - 1359-7345
SP - 2295
EP - 2296
JO - Chemical Communications
JF - Chemical Communications
IS - 19
ER -