The novel enediynes 7-9 are synthesized from xylitol 1 via the keto-enediyne 2; they are aromatized by 1,8-diazabicyclo[5.4.0]undec-7-ene in cyclohexa-1,4-diene-benzene through a radical pathway and by diethylamine in Me2SO-tris-HCl, pH 8.5 buffer through a polar pathway, and exhibit gunine-selective DNA cleavage under basic conditions with no additive.
|Number of pages||2|
|Journal||Journal of the Chemical Society, Chemical Communications|
|Publication status||Published - 1994 Dec 1|
ASJC Scopus subject areas
- Molecular Medicine