Design, cycloaromatization and guanine-selective DNA cleavage of novel enediynes

Kazunobu Toshima, Kazumi Ohta, Takaaki Kano, Takatsugu Nakamura, Masaya Nakata, Shuichi Matsumura

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Abstract

The novel enediynes 7-9 are synthesized from xylitol 1 via the keto-enediyne 2; they are aromatized by 1,8-diazabicyclo[5.4.0]undec-7-ene in cyclohexa-1,4-diene-benzene through a radical pathway and by diethylamine in Me2SO-tris-HCl, pH 8.5 buffer through a polar pathway, and exhibit gunine-selective DNA cleavage under basic conditions with no additive.

Original languageEnglish
Pages (from-to)2295-2296
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number19
DOIs
Publication statusPublished - 1994 Dec 1

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ASJC Scopus subject areas

  • Molecular Medicine

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