Design of Efficient Chiral Bifunctional Phase-Transfer Catalysts Possessing an Amino Functionality for Asymmetric Aminations

Suva Paria, Qi Kai Kang, Miho Hatanaka, Keiji Maruoka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An efficient, chiral bifunctional phase-transfer catalyst with an intramolecular amino functionality has been designed and successfully applied to highly enantioselective amination of 3-aryloxindoles and 3-arylbenzofuran-2(3H)-ones with bis(adamantyl) azodicarboxylate. Optically active amination products were generally obtained in high yield with high enantioselectivity. The origin of stereoselectivity was explained by means of the DFT calculations. ©

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalACS Catalysis
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Jan 4
Externally publishedYes

Keywords

  • asymmetric amination
  • benzofuran-2(3 H)-one
  • bifunctional catalyst
  • oxindole
  • phase-transfer catalyst

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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