Design of Glycopolymers Carrying Sialyl Oligosaccharides for Controlling the Interaction with the Influenza Virus

Masanori Nagao, Yurina Fujiwara, Teruhiko Matsubara, Yu Hoshino, Toshinori Sato, Yoshiko Miura

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We designed glycopolymers carrying sialyl oligosaccharides by "post-click" chemistry and evaluated the interaction with the influenza virus. The glycopolymer structures were synthesized in a well-controlled manner by reversible addition-fragmentation chain transfer polymerization and the Huisgen reaction. Acrylamide-type monomers were copolymerized to give hydrophilicity to the polymer backbones, and the hydrophilicity enabled the successful introduction of the oligosaccharides into the polymer backbones. The glycopolymers with different sugar densities and polymer lengths were designed for the interaction with hemagglutinin on the virus surface. The synthesized glycopolymers showed the specific molecular recognition against different types of influenza viruses depending on the sugar units (6′- or 3′-sialyllactose). The sugar density and the polymer length of the glycopolymers affected the interaction with the influenza virus. Inhibitory activity of the glycopolymer against virus infection was demonstrated.

Original languageEnglish
Pages (from-to)4385-4392
Number of pages8
JournalBiomacromolecules
Volume18
Issue number12
DOIs
Publication statusPublished - 2017 Dec 11

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Oligosaccharides
Viruses
Polymers
Sugars
Hydrophilicity
Molecular recognition
Acrylamide
Hemagglutinins
Monomers
Polymerization

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Design of Glycopolymers Carrying Sialyl Oligosaccharides for Controlling the Interaction with the Influenza Virus. / Nagao, Masanori; Fujiwara, Yurina; Matsubara, Teruhiko; Hoshino, Yu; Sato, Toshinori; Miura, Yoshiko.

In: Biomacromolecules, Vol. 18, No. 12, 11.12.2017, p. 4385-4392.

Research output: Contribution to journalArticle

Nagao, Masanori ; Fujiwara, Yurina ; Matsubara, Teruhiko ; Hoshino, Yu ; Sato, Toshinori ; Miura, Yoshiko. / Design of Glycopolymers Carrying Sialyl Oligosaccharides for Controlling the Interaction with the Influenza Virus. In: Biomacromolecules. 2017 ; Vol. 18, No. 12. pp. 4385-4392.
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