Design of microfluidic channels to prevent negative filtration in implantable hemofiltration devices

R. Kono; T. Ota; T. Ito; Y. Miyaoka; H. Ishibashi; Y. Kanno; N. Miki

doi:10.1109/EMBC46164.2021.9630070

Design of microfluidic channels to prevent negative filtration in implantable hemofiltration devices

R. Kono, T. Ota, T. Ito, Y. Miyaoka, H. Ishibashi, Y. Kanno, N. Miki

Department of Mechanical Engineering

Research output: Contribution to journal › Conference article › peer-review

Abstract

In order to improve the quality of life of dialysis patients, our group have been developing an implantable hemofiltration device (IHFD) composed of multiple layers of dialysis membranes and microfluidic channels. To improve the hemodialysis performance of IHFD, preventing the negative filtration, which is caused by the oncotic pressure of blood, is mandatory. In this study, we fabricated IHFDs with five different microchannel designs and experimentally investigated the performance of each device in in vitro experiment. In addition, the successful IHFD was further evaluated by ex vivo experiments with a beagle dog. The experiments verified the effectiveness of the microchannel design, which will be used for the IHFD for in vivo experiments with pigs in the future.

Original language	English
Pages (from-to)	5051-5054
Number of pages	4
Journal	Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
Volume	2021-January
DOIs	https://doi.org/10.1109/EMBC46164.2021.9630070
Publication status	Published - 2021
Event	43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 - Virtual, Online, Mexico Duration: 2021 Nov 1 → 2021 Nov 5

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

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10.1109/EMBC46164.2021.9630070

Cite this

Kono, R., Ota, T., Ito, T., Miyaoka, Y., Ishibashi, H., Kanno, Y., & Miki, N. (2021). Design of microfluidic channels to prevent negative filtration in implantable hemofiltration devices. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2021-January, 5051-5054. https://doi.org/10.1109/EMBC46164.2021.9630070

Design of microfluidic channels to prevent negative filtration in implantable hemofiltration devices. / Kono, R.; Ota, T.; Ito, T. et al.

In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, Vol. 2021-January, 2021, p. 5051-5054.

Research output: Contribution to journal › Conference article › peer-review

Kono, R, Ota, T, Ito, T, Miyaoka, Y, Ishibashi, H, Kanno, Y & Miki, N 2021, 'Design of microfluidic channels to prevent negative filtration in implantable hemofiltration devices', Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, vol. 2021-January, pp. 5051-5054. https://doi.org/10.1109/EMBC46164.2021.9630070

Kono R, Ota T, Ito T, Miyaoka Y, Ishibashi H, Kanno Y et al. Design of microfluidic channels to prevent negative filtration in implantable hemofiltration devices. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2021;2021-January:5051-5054. doi: 10.1109/EMBC46164.2021.9630070

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title = "Design of microfluidic channels to prevent negative filtration in implantable hemofiltration devices",

abstract = "In order to improve the quality of life of dialysis patients, our group have been developing an implantable hemofiltration device (IHFD) composed of multiple layers of dialysis membranes and microfluidic channels. To improve the hemodialysis performance of IHFD, preventing the negative filtration, which is caused by the oncotic pressure of blood, is mandatory. In this study, we fabricated IHFDs with five different microchannel designs and experimentally investigated the performance of each device in in vitro experiment. In addition, the successful IHFD was further evaluated by ex vivo experiments with a beagle dog. The experiments verified the effectiveness of the microchannel design, which will be used for the IHFD for in vivo experiments with pigs in the future.",

author = "R. Kono and T. Ota and T. Ito and Y. Miyaoka and H. Ishibashi and Y. Kanno and N. Miki",

note = "Funding Information: *Research supported by AMED Foundation. Publisher Copyright: {\textcopyright} 2021 IEEE.; 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 ; Conference date: 01-11-2021 Through 05-11-2021",

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AU - Ishibashi, H.

AU - Kanno, Y.

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AB - In order to improve the quality of life of dialysis patients, our group have been developing an implantable hemofiltration device (IHFD) composed of multiple layers of dialysis membranes and microfluidic channels. To improve the hemodialysis performance of IHFD, preventing the negative filtration, which is caused by the oncotic pressure of blood, is mandatory. In this study, we fabricated IHFDs with five different microchannel designs and experimentally investigated the performance of each device in in vitro experiment. In addition, the successful IHFD was further evaluated by ex vivo experiments with a beagle dog. The experiments verified the effectiveness of the microchannel design, which will be used for the IHFD for in vivo experiments with pigs in the future.

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Design of microfluidic channels to prevent negative filtration in implantable hemofiltration devices

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