TY - JOUR
T1 - Design of microfluidic channels to prevent negative filtration in implantable hemofiltration devices
AU - Kono, R.
AU - Ota, T.
AU - Ito, T.
AU - Miyaoka, Y.
AU - Ishibashi, H.
AU - Kanno, Y.
AU - Miki, N.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - In order to improve the quality of life of dialysis patients, our group have been developing an implantable hemofiltration device (IHFD) composed of multiple layers of dialysis membranes and microfluidic channels. To improve the hemodialysis performance of IHFD, preventing the negative filtration, which is caused by the oncotic pressure of blood, is mandatory. In this study, we fabricated IHFDs with five different microchannel designs and experimentally investigated the performance of each device in in vitro experiment. In addition, the successful IHFD was further evaluated by ex vivo experiments with a beagle dog. The experiments verified the effectiveness of the microchannel design, which will be used for the IHFD for in vivo experiments with pigs in the future.
AB - In order to improve the quality of life of dialysis patients, our group have been developing an implantable hemofiltration device (IHFD) composed of multiple layers of dialysis membranes and microfluidic channels. To improve the hemodialysis performance of IHFD, preventing the negative filtration, which is caused by the oncotic pressure of blood, is mandatory. In this study, we fabricated IHFDs with five different microchannel designs and experimentally investigated the performance of each device in in vitro experiment. In addition, the successful IHFD was further evaluated by ex vivo experiments with a beagle dog. The experiments verified the effectiveness of the microchannel design, which will be used for the IHFD for in vivo experiments with pigs in the future.
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U2 - 10.1109/EMBC46164.2021.9630070
DO - 10.1109/EMBC46164.2021.9630070
M3 - Article
C2 - 34892342
AN - SCOPUS:85122509729
VL - 2021
SP - 5051
EP - 5054
JO - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
JF - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
SN - 2694-0604
ER -