Design of spontaneously blinking fluorophores for live-cell super-resolution imaging based on quantum-chemical calculations

Ryo Tachibana, Mako Kamiya, Akihiko Morozumi, Yoshiyuki Miyazaki, Hiroyoshi Fujioka, Aika Nanjo, Ryosuke Kojima, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Toshitada Yoshihara, Seiji Tobita, Yasuteru Urano

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Spontaneously blinking fluorophores are powerful tools for live-cell super-resolution imaging under physiological conditions. Here we show that quantum-chemical calculations can predict key parameters for fluorophore design. We applied this methodology to develop a spontaneously blinking fluorophore with yellow fluorescence for super-resolution imaging of microtubules in living cells. This journal is

Original languageEnglish
Pages (from-to)13173-13176
Number of pages4
JournalChemical Communications
Volume56
Issue number86
DOIs
Publication statusPublished - 2020 Nov 7
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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