Design of VEGF releasing fiber mat for effective transplantation of cardiomyocyte sheets

Research output: Contribution to journalArticle

Abstract

Recently, cell transplantation therapy using cellular tissue has been used as an effective therapy for patient. In order to improve the efficacy of the cellular tissue transplantation, vascular endothelial growth factor (VEGF) releasing fiber mat was developed. Using the fiber mat, six layered cardiomyocyte sheets can be transplanted at once, because the local release of VEGF induced the vascularization into the transplanted stacked cardiomyocyte sheets. In this article, the design strategy of the VEGF releasing fiber mat was introduced with the background of cellular tissue transplantation.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalDrug Delivery System
Volume34
Issue number3
DOIs
Publication statusPublished - 2019 Jan 1

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Cardiac Myocytes
Vascular Endothelial Growth Factor A
Tissue Transplantation
Transplantation
Cell Transplantation
Cell- and Tissue-Based Therapy
Therapeutics

Keywords

  • Cell transplantation
  • Fiber mat
  • Nano particle
  • VEGF

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Design of VEGF releasing fiber mat for effective transplantation of cardiomyocyte sheets. / Nagase, Kenichi; Kanazawa, Hideko.

In: Drug Delivery System, Vol. 34, No. 3, 01.01.2019, p. 173-178.

Research output: Contribution to journalArticle

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