Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors

Tony K.M. Shing, Wai Lung Ng, Judy Y.W. Chan, Clara B.S. Lau

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Combating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent.

Original languageEnglish
Pages (from-to)8401-8405
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number32
DOIs
Publication statusPublished - 2013 Aug 5

Keywords

  • SGLT2
  • allylation
  • antidiabetics
  • carbohydrate mimics
  • diastereoselectivity

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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