Abstract
Combating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent.
| Original language | English |
|---|---|
| Pages (from-to) | 8401-8405 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 32 |
| DOIs | |
| Publication status | Published - 2013 Aug 5 |
| Externally published | Yes |
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Keywords
- allylation
- antidiabetics
- carbohydrate mimics
- diastereoselectivity
- SGLT2
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
Cite this
Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors. / Shing, Tony Kung Ming; Ng, Wai Lung; Chan, Judy Y W; Lau, Clara B S.
In: Angewandte Chemie - International Edition, Vol. 52, No. 32, 05.08.2013, p. 8401-8405.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors
AU - Shing, Tony Kung Ming
AU - Ng, Wai Lung
AU - Chan, Judy Y W
AU - Lau, Clara B S
PY - 2013/8/5
Y1 - 2013/8/5
N2 - Combating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent.
AB - Combating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent.
KW - allylation
KW - antidiabetics
KW - carbohydrate mimics
KW - diastereoselectivity
KW - SGLT2
UR - http://www.scopus.com/inward/record.url?scp=84882244111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882244111&partnerID=8YFLogxK
U2 - 10.1002/anie.201302543
DO - 10.1002/anie.201302543
M3 - Article
VL - 52
SP - 8401
EP - 8405
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 32
ER -