Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors

Tony K.M. Shing; Wai Lung Ng; Judy Y.W. Chan; Clara B.S. Lau

doi:10.1002/anie.201302543

Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors

Tony K.M. Shing, Wai Lung Ng, Judy Y.W. Chan, Clara B.S. Lau

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Combating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent.

Original language	English
Pages (from-to)	8401-8405
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	32
DOIs	https://doi.org/10.1002/anie.201302543
Publication status	Published - 2013 Aug 5

Keywords

SGLT2
allylation
antidiabetics
carbohydrate mimics
diastereoselectivity

ASJC Scopus subject areas

Catalysis
Chemistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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AU - Chan, Judy Y.W.

AU - Lau, Clara B.S.

PY - 2013/8/5

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AB - Combating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent.

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KW - antidiabetics

KW - carbohydrate mimics

KW - diastereoselectivity

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ER -

Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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