Abstract
Combating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent.
Original language | English |
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Pages (from-to) | 8401-8405 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 52 |
Issue number | 32 |
DOIs | |
Publication status | Published - 2013 Aug 5 |
Keywords
- SGLT2
- allylation
- antidiabetics
- carbohydrate mimics
- diastereoselectivity
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)