Abstract
Combating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent.
| Original language | English |
|---|---|
| Pages (from-to) | 8401-8405 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 32 |
| DOIs | |
| Publication status | Published - 2013 Aug 5 |
Keywords
- SGLT2
- allylation
- antidiabetics
- carbohydrate mimics
- diastereoselectivity
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
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Cite this
Shing, T. K. M., Ng, W. L., Chan, J. Y. W., & Lau, C. B. S. (2013). Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors. Angewandte Chemie - International Edition, 52(32), 8401-8405. https://doi.org/10.1002/anie.201302543