Design, synthesis, and biological evaluation of biotin-labeled (-)-ternatin, a potent fat-accumulation inhibitor against 3T3-L1 adipocytes

Kenichiro Shimokawa, Kaoru Yamada, Osamu Ohno, Yuichi Oba, Daisuke Uemura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The design, synthesis, and biological activity of biotin-labeled (-)-ternatin are reported. Chemical modification, that is, biotinylation, was conducted using Click chemistry at the 6-position (NMe-d-ProGly moiety), which was a plausible location selected on the basis of our SAR studies. The compound displayed sufficient fat-accumulation inhibitory effect against 3T3-L1 adipocytes for further bio-organic studies.

Original languageEnglish
Pages (from-to)92-95
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

Keywords

  • Biotinylation
  • Click chemistry
  • Cyclic peptide
  • Fat-accumulation inhibitory effect
  • Ternatin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Design, synthesis, and biological evaluation of biotin-labeled (-)-ternatin, a potent fat-accumulation inhibitor against 3T3-L1 adipocytes'. Together they form a unique fingerprint.

  • Cite this