Abstract
The designed hybrids 5-11 containing the DNA cleavable enediyne 4 and naturally occurring DNA intercalators 12-18cleave DNA effectively under alkaline conditions without any additive; the hybrids 5 and 11 exhibit the strongest DNA-cleaving abilities with the identical high purine base (G>A) selectivities for their DNA-cleavage profiles.
| Original language | English |
|---|---|
| Pages (from-to) | 1525-1527 |
| Number of pages | 3 |
| Journal | Journal of the Chemical Society, Chemical Communications |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 1993 Dec 1 |
ASJC Scopus subject areas
- Molecular Medicine
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Cite this
Toshima, K., Ohta, K., Ohashi, A., Nakamura, T., Nakata, M., & Matsumura, S. (1993). Design, synthesis and DNA cleaving profiles of hybrids containing the novel enediyne and naturally occurring DNA intercalates. Journal of the Chemical Society, Chemical Communications, (19), 1525-1527. https://doi.org/10.1039/C39930001525