Abstract
The designed hybrids 5-11 containing the DNA cleavable enediyne 4 and naturally occurring DNA intercalators 12-18cleave DNA effectively under alkaline conditions without any additive; the hybrids 5 and 11 exhibit the strongest DNA-cleaving abilities with the identical high purine base (G>A) selectivities for their DNA-cleavage profiles.
Original language | English |
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Pages (from-to) | 1525-1527 |
Number of pages | 3 |
Journal | Journal of the Chemical Society, Chemical Communications |
Issue number | 19 |
DOIs | |
Publication status | Published - 1993 Dec 1 |
ASJC Scopus subject areas
- Molecular Medicine