Design, synthesis and DNA cleaving profiles of hybrids containing the novel enediyne and naturally occurring DNA intercalates

Kazunobu Toshima, Kazumi Ohta, Aya Ohashi, Takatsugu Nakamura, Masaya Nakata, Shuichi Matsumura

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The designed hybrids 5-11 containing the DNA cleavable enediyne 4 and naturally occurring DNA intercalators 12-18cleave DNA effectively under alkaline conditions without any additive; the hybrids 5 and 11 exhibit the strongest DNA-cleaving abilities with the identical high purine base (G>A) selectivities for their DNA-cleavage profiles.

Original languageEnglish
Pages (from-to)1525-1527
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number19
DOIs
Publication statusPublished - 1993 Dec 1

ASJC Scopus subject areas

  • Molecular Medicine

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