Design, synthesis and DNA cleaving profiles of hybrids containing the novel enediyne and naturally occurring DNA intercalates

Kazunobu Toshima; Kazumi Ohta; Aya Ohashi; Takatsugu Nakamura; Masaya Nakata; Shuichi Matsumura

doi:10.1039/C39930001525

Design, synthesis and DNA cleaving profiles of hybrids containing the novel enediyne and naturally occurring DNA intercalates

Kazunobu Toshima, Kazumi Ohta, Aya Ohashi, Takatsugu Nakamura, Masaya Nakata, Shuichi Matsumura

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The designed hybrids 5-11 containing the DNA cleavable enediyne 4 and naturally occurring DNA intercalators 12-18cleave DNA effectively under alkaline conditions without any additive; the hybrids 5 and 11 exhibit the strongest DNA-cleaving abilities with the identical high purine base (G>A) selectivities for their DNA-cleavage profiles.

Original language	English
Pages (from-to)	1525-1527
Number of pages	3
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	19
DOIs	https://doi.org/10.1039/C39930001525
Publication status	Published - 1993 Dec 1

ASJC Scopus subject areas

Molecular Medicine

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10.1039/C39930001525

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abstract = "The designed hybrids 5-11 containing the DNA cleavable enediyne 4 and naturally occurring DNA intercalators 12-18cleave DNA effectively under alkaline conditions without any additive; the hybrids 5 and 11 exhibit the strongest DNA-cleaving abilities with the identical high purine base (G>A) selectivities for their DNA-cleavage profiles.",

author = "Kazunobu Toshima and Kazumi Ohta and Aya Ohashi and Takatsugu Nakamura and Masaya Nakata and Shuichi Matsumura",

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AU - Nakamura, Takatsugu

AU - Nakata, Masaya

AU - Matsumura, Shuichi

PY - 1993/12/1

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AB - The designed hybrids 5-11 containing the DNA cleavable enediyne 4 and naturally occurring DNA intercalators 12-18cleave DNA effectively under alkaline conditions without any additive; the hybrids 5 and 11 exhibit the strongest DNA-cleaving abilities with the identical high purine base (G>A) selectivities for their DNA-cleavage profiles.

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Design, synthesis and DNA cleaving profiles of hybrids containing the novel enediyne and naturally occurring DNA intercalates

Abstract

ASJC Scopus subject areas

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