Desmoglein 3-Reactive B Cells “Hiding” in Pemphigus Lesions

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Abstract

Pemphigus vulgaris is an autoimmune blistering disease caused by anti-desmoglein 3 IgG autoantibodies. It is accepted that interactions between autoreactive B and T cells are key to humoral autoimmunity targeting desmoglein 3. This orchestrated process usually occurs in secondary lymphoid organs, including the spleen and lymph nodes. Thus, it seems likely that autoreactive B cells reside and produce autoantibodies in these tissues. Yuan et al. analyzed lymphocytes in the lesional skin of patients with pemphigus vulgaris using several experimental techniques and concluded that desmoglein 3-reactive B cells were present. This finding expands our understanding of the pathogenesis of pemphigus and should be considered when following the clinical course of skin lesions and thinking about adjunctive therapy.

Original languageEnglish
Pages (from-to)2255-2257
Number of pages3
JournalJournal of Investigative Dermatology
Volume137
Issue number11
DOIs
Publication statusPublished - 2017 Nov 1

Fingerprint

Desmoglein 3
Pemphigus
B-Lymphocytes
Cells
Autoantibodies
Skin
T-cells
Lymphocytes
Autoimmunity
Autoimmune Diseases
Spleen
Immunoglobulin G
Lymph Nodes
Tissue
T-Lymphocytes
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Desmoglein 3-Reactive B Cells “Hiding” in Pemphigus Lesions. / Takahashi, Hayato.

In: Journal of Investigative Dermatology, Vol. 137, No. 11, 01.11.2017, p. 2255-2257.

Research output: Contribution to journalComment/debate

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