[Destruction of the articular cartilage in osteoarthritis].

Masashi Okubo, Yasunori Okada

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)


Osteoarthritis (OA) is the most common joint disease characterized by destruction of articular cartilage induced primarily by mechanical stresses to joints. Destruction of the articular cartilage in OA is caused by combination of increased degradation of ECM (extracellular matrix) , decreased production of ECM and chondrocyte death. Members of the MMP (matrix metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) gene families are considered to play a key role in the degradation of cartilage.

Original languageEnglish
Pages (from-to)1705-1713
Number of pages9
JournalClinical calcium
Issue number12
Publication statusPublished - 2013 Dec

ASJC Scopus subject areas

  • Medicine(all)


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