Desymmetrization of prochiral methylenes by asymmetric chain-walking cyclization using bioxazoline palladium catalysts

Masayuki Shigekane, Tomonori Arai, Makoto Tamura, Tatsuya Uchida, Fumitoshi Kakiuchi, Takuya Kochi

Research output: Contribution to journalArticlepeer-review

Abstract

We present here that the use of bioxazoline ligands improved the enantioselectivity of the palladium-catalyzed chain-walking cycloisomerization of 1,n-dienes. The new system was applied to the asymmetric chain-walking cycloisomerization of a variety of 1,n-dienes as well as asymmetric hydrosilylation/cyclization of a 1,8-diene.

Original languageEnglish
Article number154292
JournalTetrahedron Letters
Volume114
DOIs
Publication statusPublished - 2023 Jan 12

Keywords

  • Asymmetric cycloisomerization
  • Bioxazoline ligands
  • Chain walking
  • Palladium catalysts
  • Remote Functionalization

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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