Detection of attenuated plaque in stable angina with 64-multidetector computed tomography

A comparison with intravascular ultrasound

Masahiro Jinzaki, Teruo Okabe, Ayaka Endo, Akio Kawamura, Seiko Koga, Minoru Yamada, Keiichi Fukuda, Sachio Kuribayashi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: To clarify multidetector computed tomography (MDCT) findings of attenuated plaque detected by intravascular ultrasound (IVUS). Methods and Results: One hundred and fifty-four patients with stable angina underwent MDCT before IVUS. The attenuated plaque was identified in the targeted artery with IVUS, and the same artery was analyzed with MDCT for the presence of a high density area (HDA) >130 Hounsfield units (HU), and a low density area (LDA) <30 HU. A HDA in attenuated plaque was compared with that in calcified plaque. Ten attenuated plaques and 15 calcified plaques were identified in 9 of 154 patients (males=9, 66.2±9.5 years). Eight of the 10 attenuated plaques and all 15 calcified plaques were accompanied with a HDA on MDCT. The HDA ranged from 174 to 667 HU (mean 389.0±148.3 HU) in the 8 attenuated plaques, and from 545 to 1,205 HU (mean 920.9±215.9 HU) in 15 calcified plaques. There was a significant difference in CT density of the HDA between the attenuated and calcified plaque (P<0.001). All attenuated plaques contained LDA <30 HU in the portions without HDA. Conclusions: MDCT has the ability to demonstrate attenuated plaque as the combination of HDA (approximately 400 HU on average) and LDA <30 HU. The HDA can be differentiated from calcified plaque by its lower CT density value.

Original languageEnglish
Pages (from-to)1182-1189
Number of pages8
JournalCirculation Journal
Volume76
Issue number5
DOIs
Publication statusPublished - 2012

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Stable Angina
Multidetector Computed Tomography
Arteries

Keywords

  • Attenuated plaque
  • Computed tomography
  • Coronary artery
  • Intravascular ultrasound
  • Vulnerability

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Detection of attenuated plaque in stable angina with 64-multidetector computed tomography : A comparison with intravascular ultrasound. / Jinzaki, Masahiro; Okabe, Teruo; Endo, Ayaka; Kawamura, Akio; Koga, Seiko; Yamada, Minoru; Fukuda, Keiichi; Kuribayashi, Sachio.

In: Circulation Journal, Vol. 76, No. 5, 2012, p. 1182-1189.

Research output: Contribution to journalArticle

Jinzaki, Masahiro ; Okabe, Teruo ; Endo, Ayaka ; Kawamura, Akio ; Koga, Seiko ; Yamada, Minoru ; Fukuda, Keiichi ; Kuribayashi, Sachio. / Detection of attenuated plaque in stable angina with 64-multidetector computed tomography : A comparison with intravascular ultrasound. In: Circulation Journal. 2012 ; Vol. 76, No. 5. pp. 1182-1189.
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N2 - Background: To clarify multidetector computed tomography (MDCT) findings of attenuated plaque detected by intravascular ultrasound (IVUS). Methods and Results: One hundred and fifty-four patients with stable angina underwent MDCT before IVUS. The attenuated plaque was identified in the targeted artery with IVUS, and the same artery was analyzed with MDCT for the presence of a high density area (HDA) >130 Hounsfield units (HU), and a low density area (LDA) <30 HU. A HDA in attenuated plaque was compared with that in calcified plaque. Ten attenuated plaques and 15 calcified plaques were identified in 9 of 154 patients (males=9, 66.2±9.5 years). Eight of the 10 attenuated plaques and all 15 calcified plaques were accompanied with a HDA on MDCT. The HDA ranged from 174 to 667 HU (mean 389.0±148.3 HU) in the 8 attenuated plaques, and from 545 to 1,205 HU (mean 920.9±215.9 HU) in 15 calcified plaques. There was a significant difference in CT density of the HDA between the attenuated and calcified plaque (P<0.001). All attenuated plaques contained LDA <30 HU in the portions without HDA. Conclusions: MDCT has the ability to demonstrate attenuated plaque as the combination of HDA (approximately 400 HU on average) and LDA <30 HU. The HDA can be differentiated from calcified plaque by its lower CT density value.

AB - Background: To clarify multidetector computed tomography (MDCT) findings of attenuated plaque detected by intravascular ultrasound (IVUS). Methods and Results: One hundred and fifty-four patients with stable angina underwent MDCT before IVUS. The attenuated plaque was identified in the targeted artery with IVUS, and the same artery was analyzed with MDCT for the presence of a high density area (HDA) >130 Hounsfield units (HU), and a low density area (LDA) <30 HU. A HDA in attenuated plaque was compared with that in calcified plaque. Ten attenuated plaques and 15 calcified plaques were identified in 9 of 154 patients (males=9, 66.2±9.5 years). Eight of the 10 attenuated plaques and all 15 calcified plaques were accompanied with a HDA on MDCT. The HDA ranged from 174 to 667 HU (mean 389.0±148.3 HU) in the 8 attenuated plaques, and from 545 to 1,205 HU (mean 920.9±215.9 HU) in 15 calcified plaques. There was a significant difference in CT density of the HDA between the attenuated and calcified plaque (P<0.001). All attenuated plaques contained LDA <30 HU in the portions without HDA. Conclusions: MDCT has the ability to demonstrate attenuated plaque as the combination of HDA (approximately 400 HU on average) and LDA <30 HU. The HDA can be differentiated from calcified plaque by its lower CT density value.

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