Detection of C-Type Natriuretic Peptide in Human Circulation and Marked Increase of Plasma CNP Level in Septic Shock Patients

N. Hama, Hiroshi Itoh, G. Shirakami, S. Suga, Y. Komatsu, T. Yoshimasa, I. Tanaka, K. Mori, K. Nakao

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

We have previously reported that C-type natriuretic peptide (CNP), the third member of natriuretic family, was produced in vascular endothelial cells and hypothesized that CNP might be a local regulator of vascular tone and/or growth from endothelial cells. In order to clarify the pathophysiological significance of CNP in humans, we examined the presence of CNP in human circulation and determined plasma levels of CNP in patients with various cardiovascular disorders. The plasma level of CNP in healthy persons was 1.4 ± 0.6 fmol/ml (n=13). The plasma level of CNP was markedly increased in patients with septic shock (13.2 ± 10.1 fmol/ml, n=11), while there was no alteration in patients with congestive heart failure or hypertension. There was two-fold increase of the plasma CNP level in patients with chronic renal failure. These results indicate that CNP, which can be considered as an endothelium-derived relaxing peptide, is detectable in human circulation and suggest the pathophysiological significance of endothelial CNP in humans.

Original languageEnglish
Pages (from-to)1177-1182
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume198
Issue number3
DOIs
Publication statusPublished - 1994 Feb 14
Externally publishedYes

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C-Type Natriuretic Peptide
Septic Shock
Plasmas
Endothelial cells
Endothelial Cells
Chronic Kidney Failure
Endothelium
Blood Vessels
Heart Failure

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry

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Detection of C-Type Natriuretic Peptide in Human Circulation and Marked Increase of Plasma CNP Level in Septic Shock Patients. / Hama, N.; Itoh, Hiroshi; Shirakami, G.; Suga, S.; Komatsu, Y.; Yoshimasa, T.; Tanaka, I.; Mori, K.; Nakao, K.

In: Biochemical and Biophysical Research Communications, Vol. 198, No. 3, 14.02.1994, p. 1177-1182.

Research output: Contribution to journalArticle

Hama, N. ; Itoh, Hiroshi ; Shirakami, G. ; Suga, S. ; Komatsu, Y. ; Yoshimasa, T. ; Tanaka, I. ; Mori, K. ; Nakao, K. / Detection of C-Type Natriuretic Peptide in Human Circulation and Marked Increase of Plasma CNP Level in Septic Shock Patients. In: Biochemical and Biophysical Research Communications. 1994 ; Vol. 198, No. 3. pp. 1177-1182.
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