Detection of carotid atherosclerosis in individuals with masked hypertension and white-coat hypertension by self-measured blood pressure at home: The Ohasama study

Azusa Hara, Takayoshi Ohkubo, Masahiro Kikuya, Yoriko Shintani, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Takanao Hashimoto, Toshiya Harasawa, Yoko Aono, Harunori Otani, Kazushi Tanaka, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

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79 Citations (Scopus)

Abstract

OBJECTIVE: To investigate carotid atherosclerosis in individuals with masked hypertension (MHT) and white-coat hypertension (WCHT) in a general population. METHODS: Self-measurement of blood pressure at home (HBP) and casual blood pressure (CBP) measurements were recorded in 812 individuals aged at least 55 years (mean 66.4 years) from the general Japanese population. The intima-media thickness (IMT) of the near and far wall of both common carotid arteries was measured and averaged. The relationships between carotid atherosclerosis (IMT and plaque) and the four blood pressure groups (sustained normal blood pressure: HBP < 135/85 mmHg, CBP < 140/90 mmHg; WCHT: HBP < 135/85 mmHg, CBP ≥ 140/90 mmHg; MHT: HBP ≥ 135/85 mmHg, CBP < 140/90 mmHg; sustained hypertension: HBP ≥ 135/85 mmHg, CBP ≥ 140/90 mmHg) were examined using multivariate analysis adjusted for possible confounding factors. RESULTS: Adjusted IMT in individuals with sustained hypertension [0.77 mm; 95% confidence interval (CI) 0.75 to 0.79 mm] and MHT (0.77 mm; 95% CI 0.73 to 0.80 mm) was significantly greater than in those with sustained normal blood pressure (0.71 mm; 95% CI 0.69 to 0.72 mm) and WCHT (0.72 mm; 95% CI 0.71 to 0.74 mm) (P < 0.0001). The odds ratios for the presence of plaques in all four groups were similar to the trends in IMT. CONCLUSIONS: Our findings imply that CBP measurements alone are insufficient to distinguish individuals at high risk of carotid atherosclerosis from those at low risk. However, these individuals do have distinct HBP measurements, suggesting that HBP measurement could become a valuable tool for predicting carotid atherosclerosis.

Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalJournal of hypertension
Volume25
Issue number2
DOIs
Publication statusPublished - 2007 Feb 1
Externally publishedYes

Keywords

  • Carotid atherosclerosis
  • General population
  • Home blood pressure
  • Masked hypertension
  • White-coat hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Hara, A., Ohkubo, T., Kikuya, M., Shintani, Y., Obara, T., Metoki, H., Inoue, R., Asayama, K., Hashimoto, T., Harasawa, T., Aono, Y., Otani, H., Tanaka, K., Hashimoto, J., Totsune, K., Hoshi, H., Satoh, H., & Imai, Y. (2007). Detection of carotid atherosclerosis in individuals with masked hypertension and white-coat hypertension by self-measured blood pressure at home: The Ohasama study. Journal of hypertension, 25(2), 321-327. https://doi.org/10.1097/HJH.0b013e3280115bbf