Detection of carotid atherosclerosis in individuals with masked hypertension and white-coat hypertension by self-measured blood pressure at home: The Ohasama study

Azusa Hara, Takayoshi Ohkubo, Masahiro Kikuya, Yoriko Shintani, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Takanao Hashimoto, Toshiya Harasawa, Yoko Aono, Harunori Otani, Kazushi Tanaka, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

OBJECTIVE: To investigate carotid atherosclerosis in individuals with masked hypertension (MHT) and white-coat hypertension (WCHT) in a general population. METHODS: Self-measurement of blood pressure at home (HBP) and casual blood pressure (CBP) measurements were recorded in 812 individuals aged at least 55 years (mean 66.4 years) from the general Japanese population. The intima-media thickness (IMT) of the near and far wall of both common carotid arteries was measured and averaged. The relationships between carotid atherosclerosis (IMT and plaque) and the four blood pressure groups (sustained normal blood pressure: HBP < 135/85 mmHg, CBP < 140/90 mmHg; WCHT: HBP < 135/85 mmHg, CBP ≥ 140/90 mmHg; MHT: HBP ≥ 135/85 mmHg, CBP < 140/90 mmHg; sustained hypertension: HBP ≥ 135/85 mmHg, CBP ≥ 140/90 mmHg) were examined using multivariate analysis adjusted for possible confounding factors. RESULTS: Adjusted IMT in individuals with sustained hypertension [0.77 mm; 95% confidence interval (CI) 0.75 to 0.79 mm] and MHT (0.77 mm; 95% CI 0.73 to 0.80 mm) was significantly greater than in those with sustained normal blood pressure (0.71 mm; 95% CI 0.69 to 0.72 mm) and WCHT (0.72 mm; 95% CI 0.71 to 0.74 mm) (P < 0.0001). The odds ratios for the presence of plaques in all four groups were similar to the trends in IMT. CONCLUSIONS: Our findings imply that CBP measurements alone are insufficient to distinguish individuals at high risk of carotid atherosclerosis from those at low risk. However, these individuals do have distinct HBP measurements, suggesting that HBP measurement could become a valuable tool for predicting carotid atherosclerosis.

Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalJournal of hypertension
Volume25
Issue number2
DOIs
Publication statusPublished - 2007 Feb 1
Externally publishedYes

Fingerprint

Masked Hypertension
White Coat Hypertension
Carotid Artery Diseases
Blood Pressure
Confidence Intervals
Hypertension
Carotid Intima-Media Thickness
Common Carotid Artery
Blood Group Antigens
Population

Keywords

  • Carotid atherosclerosis
  • General population
  • Home blood pressure
  • Masked hypertension
  • White-coat hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Detection of carotid atherosclerosis in individuals with masked hypertension and white-coat hypertension by self-measured blood pressure at home : The Ohasama study. / Hara, Azusa; Ohkubo, Takayoshi; Kikuya, Masahiro; Shintani, Yoriko; Obara, Taku; Metoki, Hirohito; Inoue, Ryusuke; Asayama, Kei; Hashimoto, Takanao; Harasawa, Toshiya; Aono, Yoko; Otani, Harunori; Tanaka, Kazushi; Hashimoto, Junichiro; Totsune, Kazuhito; Hoshi, Haruhisa; Satoh, Hiroshi; Imai, Yutaka.

In: Journal of hypertension, Vol. 25, No. 2, 01.02.2007, p. 321-327.

Research output: Contribution to journalArticle

Hara, A, Ohkubo, T, Kikuya, M, Shintani, Y, Obara, T, Metoki, H, Inoue, R, Asayama, K, Hashimoto, T, Harasawa, T, Aono, Y, Otani, H, Tanaka, K, Hashimoto, J, Totsune, K, Hoshi, H, Satoh, H & Imai, Y 2007, 'Detection of carotid atherosclerosis in individuals with masked hypertension and white-coat hypertension by self-measured blood pressure at home: The Ohasama study', Journal of hypertension, vol. 25, no. 2, pp. 321-327. https://doi.org/10.1097/HJH.0b013e3280115bbf
Hara, Azusa ; Ohkubo, Takayoshi ; Kikuya, Masahiro ; Shintani, Yoriko ; Obara, Taku ; Metoki, Hirohito ; Inoue, Ryusuke ; Asayama, Kei ; Hashimoto, Takanao ; Harasawa, Toshiya ; Aono, Yoko ; Otani, Harunori ; Tanaka, Kazushi ; Hashimoto, Junichiro ; Totsune, Kazuhito ; Hoshi, Haruhisa ; Satoh, Hiroshi ; Imai, Yutaka. / Detection of carotid atherosclerosis in individuals with masked hypertension and white-coat hypertension by self-measured blood pressure at home : The Ohasama study. In: Journal of hypertension. 2007 ; Vol. 25, No. 2. pp. 321-327.
@article{a21f6ca25c114f2089420469638bf50f,
title = "Detection of carotid atherosclerosis in individuals with masked hypertension and white-coat hypertension by self-measured blood pressure at home: The Ohasama study",
abstract = "OBJECTIVE: To investigate carotid atherosclerosis in individuals with masked hypertension (MHT) and white-coat hypertension (WCHT) in a general population. METHODS: Self-measurement of blood pressure at home (HBP) and casual blood pressure (CBP) measurements were recorded in 812 individuals aged at least 55 years (mean 66.4 years) from the general Japanese population. The intima-media thickness (IMT) of the near and far wall of both common carotid arteries was measured and averaged. The relationships between carotid atherosclerosis (IMT and plaque) and the four blood pressure groups (sustained normal blood pressure: HBP < 135/85 mmHg, CBP < 140/90 mmHg; WCHT: HBP < 135/85 mmHg, CBP ≥ 140/90 mmHg; MHT: HBP ≥ 135/85 mmHg, CBP < 140/90 mmHg; sustained hypertension: HBP ≥ 135/85 mmHg, CBP ≥ 140/90 mmHg) were examined using multivariate analysis adjusted for possible confounding factors. RESULTS: Adjusted IMT in individuals with sustained hypertension [0.77 mm; 95{\%} confidence interval (CI) 0.75 to 0.79 mm] and MHT (0.77 mm; 95{\%} CI 0.73 to 0.80 mm) was significantly greater than in those with sustained normal blood pressure (0.71 mm; 95{\%} CI 0.69 to 0.72 mm) and WCHT (0.72 mm; 95{\%} CI 0.71 to 0.74 mm) (P < 0.0001). The odds ratios for the presence of plaques in all four groups were similar to the trends in IMT. CONCLUSIONS: Our findings imply that CBP measurements alone are insufficient to distinguish individuals at high risk of carotid atherosclerosis from those at low risk. However, these individuals do have distinct HBP measurements, suggesting that HBP measurement could become a valuable tool for predicting carotid atherosclerosis.",
keywords = "Carotid atherosclerosis, General population, Home blood pressure, Masked hypertension, White-coat hypertension",
author = "Azusa Hara and Takayoshi Ohkubo and Masahiro Kikuya and Yoriko Shintani and Taku Obara and Hirohito Metoki and Ryusuke Inoue and Kei Asayama and Takanao Hashimoto and Toshiya Harasawa and Yoko Aono and Harunori Otani and Kazushi Tanaka and Junichiro Hashimoto and Kazuhito Totsune and Haruhisa Hoshi and Hiroshi Satoh and Yutaka Imai",
year = "2007",
month = "2",
day = "1",
doi = "10.1097/HJH.0b013e3280115bbf",
language = "English",
volume = "25",
pages = "321--327",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Detection of carotid atherosclerosis in individuals with masked hypertension and white-coat hypertension by self-measured blood pressure at home

T2 - The Ohasama study

AU - Hara, Azusa

AU - Ohkubo, Takayoshi

AU - Kikuya, Masahiro

AU - Shintani, Yoriko

AU - Obara, Taku

AU - Metoki, Hirohito

AU - Inoue, Ryusuke

AU - Asayama, Kei

AU - Hashimoto, Takanao

AU - Harasawa, Toshiya

AU - Aono, Yoko

AU - Otani, Harunori

AU - Tanaka, Kazushi

AU - Hashimoto, Junichiro

AU - Totsune, Kazuhito

AU - Hoshi, Haruhisa

AU - Satoh, Hiroshi

AU - Imai, Yutaka

PY - 2007/2/1

Y1 - 2007/2/1

N2 - OBJECTIVE: To investigate carotid atherosclerosis in individuals with masked hypertension (MHT) and white-coat hypertension (WCHT) in a general population. METHODS: Self-measurement of blood pressure at home (HBP) and casual blood pressure (CBP) measurements were recorded in 812 individuals aged at least 55 years (mean 66.4 years) from the general Japanese population. The intima-media thickness (IMT) of the near and far wall of both common carotid arteries was measured and averaged. The relationships between carotid atherosclerosis (IMT and plaque) and the four blood pressure groups (sustained normal blood pressure: HBP < 135/85 mmHg, CBP < 140/90 mmHg; WCHT: HBP < 135/85 mmHg, CBP ≥ 140/90 mmHg; MHT: HBP ≥ 135/85 mmHg, CBP < 140/90 mmHg; sustained hypertension: HBP ≥ 135/85 mmHg, CBP ≥ 140/90 mmHg) were examined using multivariate analysis adjusted for possible confounding factors. RESULTS: Adjusted IMT in individuals with sustained hypertension [0.77 mm; 95% confidence interval (CI) 0.75 to 0.79 mm] and MHT (0.77 mm; 95% CI 0.73 to 0.80 mm) was significantly greater than in those with sustained normal blood pressure (0.71 mm; 95% CI 0.69 to 0.72 mm) and WCHT (0.72 mm; 95% CI 0.71 to 0.74 mm) (P < 0.0001). The odds ratios for the presence of plaques in all four groups were similar to the trends in IMT. CONCLUSIONS: Our findings imply that CBP measurements alone are insufficient to distinguish individuals at high risk of carotid atherosclerosis from those at low risk. However, these individuals do have distinct HBP measurements, suggesting that HBP measurement could become a valuable tool for predicting carotid atherosclerosis.

AB - OBJECTIVE: To investigate carotid atherosclerosis in individuals with masked hypertension (MHT) and white-coat hypertension (WCHT) in a general population. METHODS: Self-measurement of blood pressure at home (HBP) and casual blood pressure (CBP) measurements were recorded in 812 individuals aged at least 55 years (mean 66.4 years) from the general Japanese population. The intima-media thickness (IMT) of the near and far wall of both common carotid arteries was measured and averaged. The relationships between carotid atherosclerosis (IMT and plaque) and the four blood pressure groups (sustained normal blood pressure: HBP < 135/85 mmHg, CBP < 140/90 mmHg; WCHT: HBP < 135/85 mmHg, CBP ≥ 140/90 mmHg; MHT: HBP ≥ 135/85 mmHg, CBP < 140/90 mmHg; sustained hypertension: HBP ≥ 135/85 mmHg, CBP ≥ 140/90 mmHg) were examined using multivariate analysis adjusted for possible confounding factors. RESULTS: Adjusted IMT in individuals with sustained hypertension [0.77 mm; 95% confidence interval (CI) 0.75 to 0.79 mm] and MHT (0.77 mm; 95% CI 0.73 to 0.80 mm) was significantly greater than in those with sustained normal blood pressure (0.71 mm; 95% CI 0.69 to 0.72 mm) and WCHT (0.72 mm; 95% CI 0.71 to 0.74 mm) (P < 0.0001). The odds ratios for the presence of plaques in all four groups were similar to the trends in IMT. CONCLUSIONS: Our findings imply that CBP measurements alone are insufficient to distinguish individuals at high risk of carotid atherosclerosis from those at low risk. However, these individuals do have distinct HBP measurements, suggesting that HBP measurement could become a valuable tool for predicting carotid atherosclerosis.

KW - Carotid atherosclerosis

KW - General population

KW - Home blood pressure

KW - Masked hypertension

KW - White-coat hypertension

UR - http://www.scopus.com/inward/record.url?scp=33846037365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846037365&partnerID=8YFLogxK

U2 - 10.1097/HJH.0b013e3280115bbf

DO - 10.1097/HJH.0b013e3280115bbf

M3 - Article

C2 - 17211239

AN - SCOPUS:33846037365

VL - 25

SP - 321

EP - 327

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 2

ER -