Detection of hypofrontality in drivers with Alzheimer's disease by near-infrared spectroscopy

Hiroi Tomioka; Bun Yamagata; Taro Takahashi; Madoka Yano; Angelica J. Isomura; Hitomi Kobayashi; Masaru Mimura

doi:10.1016/j.neulet.2008.12.059

Detection of hypofrontality in drivers with Alzheimer's disease by near-infrared spectroscopy

Hiroi Tomioka, Bun Yamagata, Taro Takahashi, Madoka Yano, Angelica J. Isomura, Hitomi Kobayashi, Masaru Mimura

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

It is important to appropriately evaluate the driving performance of elderly persons. In the present study, near-infrared spectroscopy (NIRS) was employed to investigate differences of brain function between individuals with Alzheimer's disease (n = 12) and healthy elderly controls (n = 14) while they were being tested using a driving simulator. Changes of the oxyhemoglobin level in the prefrontal areas of each subject were measured by NIRS during a driving task (collision avoidance). Compared with healthy controls, the Alzheimer's disease group showed a less prominent increase of oxyhemoglobin in the prefrontal cortex during the collision avoidance task. The correlation between delay in braking and changes of oxyhemoglobin was positive in the healthy controls and negative in the Alzheimer's disease group, suggesting that a task-related prefrontal increase of oxyhemoglobin has different implications under normal and pathological conditions. NIRS is a potentially useful tool for real-time monitoring of prefrontal activity during simulated or actual driving.

Original language	English
Pages (from-to)	252-256
Number of pages	5
Journal	Neuroscience Letters
Volume	451
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2008.12.059
Publication status	Published - 2009 Feb 27
Externally published	Yes

Keywords

Alzheimer's disease
Dementia
Driving evaluation
Driving simulator
Near-infrared spectroscopy
Prefrontal cortex

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/j.neulet.2008.12.059

Cite this

@article{0f3e34e6163c4e959e913397b85b63b1,

title = "Detection of hypofrontality in drivers with Alzheimer's disease by near-infrared spectroscopy",

abstract = "It is important to appropriately evaluate the driving performance of elderly persons. In the present study, near-infrared spectroscopy (NIRS) was employed to investigate differences of brain function between individuals with Alzheimer's disease (n = 12) and healthy elderly controls (n = 14) while they were being tested using a driving simulator. Changes of the oxyhemoglobin level in the prefrontal areas of each subject were measured by NIRS during a driving task (collision avoidance). Compared with healthy controls, the Alzheimer's disease group showed a less prominent increase of oxyhemoglobin in the prefrontal cortex during the collision avoidance task. The correlation between delay in braking and changes of oxyhemoglobin was positive in the healthy controls and negative in the Alzheimer's disease group, suggesting that a task-related prefrontal increase of oxyhemoglobin has different implications under normal and pathological conditions. NIRS is a potentially useful tool for real-time monitoring of prefrontal activity during simulated or actual driving.",

keywords = "Alzheimer's disease, Dementia, Driving evaluation, Driving simulator, Near-infrared spectroscopy, Prefrontal cortex",

author = "Hiroi Tomioka and Bun Yamagata and Taro Takahashi and Madoka Yano and Isomura, {Angelica J.} and Hitomi Kobayashi and Masaru Mimura",

note = "Funding Information: This study was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology to M.M. We thank Mr. Shingo Kawasaki of Hitachi Corporation for his help in preparing the manuscript.",

year = "2009",

month = feb,

day = "27",

doi = "10.1016/j.neulet.2008.12.059",

language = "English",

volume = "451",

pages = "252--256",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Detection of hypofrontality in drivers with Alzheimer's disease by near-infrared spectroscopy

AU - Tomioka, Hiroi

AU - Yamagata, Bun

AU - Takahashi, Taro

AU - Yano, Madoka

AU - Isomura, Angelica J.

AU - Kobayashi, Hitomi

AU - Mimura, Masaru

N1 - Funding Information: This study was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology to M.M. We thank Mr. Shingo Kawasaki of Hitachi Corporation for his help in preparing the manuscript.

PY - 2009/2/27

Y1 - 2009/2/27

N2 - It is important to appropriately evaluate the driving performance of elderly persons. In the present study, near-infrared spectroscopy (NIRS) was employed to investigate differences of brain function between individuals with Alzheimer's disease (n = 12) and healthy elderly controls (n = 14) while they were being tested using a driving simulator. Changes of the oxyhemoglobin level in the prefrontal areas of each subject were measured by NIRS during a driving task (collision avoidance). Compared with healthy controls, the Alzheimer's disease group showed a less prominent increase of oxyhemoglobin in the prefrontal cortex during the collision avoidance task. The correlation between delay in braking and changes of oxyhemoglobin was positive in the healthy controls and negative in the Alzheimer's disease group, suggesting that a task-related prefrontal increase of oxyhemoglobin has different implications under normal and pathological conditions. NIRS is a potentially useful tool for real-time monitoring of prefrontal activity during simulated or actual driving.

AB - It is important to appropriately evaluate the driving performance of elderly persons. In the present study, near-infrared spectroscopy (NIRS) was employed to investigate differences of brain function between individuals with Alzheimer's disease (n = 12) and healthy elderly controls (n = 14) while they were being tested using a driving simulator. Changes of the oxyhemoglobin level in the prefrontal areas of each subject were measured by NIRS during a driving task (collision avoidance). Compared with healthy controls, the Alzheimer's disease group showed a less prominent increase of oxyhemoglobin in the prefrontal cortex during the collision avoidance task. The correlation between delay in braking and changes of oxyhemoglobin was positive in the healthy controls and negative in the Alzheimer's disease group, suggesting that a task-related prefrontal increase of oxyhemoglobin has different implications under normal and pathological conditions. NIRS is a potentially useful tool for real-time monitoring of prefrontal activity during simulated or actual driving.

KW - Alzheimer's disease

KW - Dementia

KW - Driving evaluation

KW - Driving simulator

KW - Near-infrared spectroscopy

KW - Prefrontal cortex

UR - http://www.scopus.com/inward/record.url?scp=59149091441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59149091441&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2008.12.059

DO - 10.1016/j.neulet.2008.12.059

M3 - Article

C2 - 19146927

AN - SCOPUS:59149091441

SN - 0304-3940

VL - 451

SP - 252

EP - 256

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Detection of hypofrontality in drivers with Alzheimer's disease by near-infrared spectroscopy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this