Detection of iron deposition in dermal fibrocytes is a useful tool for histologic diagnosis of nephrogenic systemic fibrosis

Julia Miyamoto, Akiko Tanikawa, Atsuyuki Igarashi, Hiroshi Hataya, Ken Kobayashi, Masahiro Ikegami, Akihiro Sotome, Yayoi Nagai, Kaori Kameyama, Akira Ishiko

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Nephrogenic systemic fibrosis (NSF) is a fibrotic disease that presents with a history of renal dysfunction. The differential diagnosis generally includes scleromyxedema, systemic sclerosis, and morphea. Especially, scleromyxedema can be extremely difficult to distinguish microscopically. Although the fibrocytes in NSF are often positive for CD34 and procollagen-I, this is not specific for NSF. We identified positive iron staining in the skin of a patient with NSF and investigated whether this was a specific feature among 9 patients with NSF reported in Japan. We found that 6 of 9 patients showed positive iron staining in the dermal fibrocytes. The amount of iron deposition seemed to have no correlation with the degree of fibrosis or duration of the skin lesions but correlated with apparent history of the use of gadolinium-based contrast agents. As controls, skin biopsies from patients with scleromyxedema, morphea, and systemic sclerosis were evaluated by iron staining. None of these control patients showed iron deposition, indicating that positive iron staining may be specific to NSF and can be a useful tool for NSF diagnosis.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalAmerican Journal of Dermatopathology
Volume33
Issue number3
DOIs
Publication statusPublished - 2011 May

Fingerprint

Nephrogenic Fibrosing Dermopathy
Iron
Scleromyxedema
Skin
Staining and Labeling
Localized Scleroderma
Systemic Scleroderma
Procollagen
Gadolinium
Contrast Media
Japan
Differential Diagnosis
Fibrosis
Kidney
Biopsy

Keywords

  • gadolinium
  • iron
  • magnetic resonance imaging
  • nephrogenic fibrosing dermopathy
  • renal insufficiency

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

Cite this

Detection of iron deposition in dermal fibrocytes is a useful tool for histologic diagnosis of nephrogenic systemic fibrosis. / Miyamoto, Julia; Tanikawa, Akiko; Igarashi, Atsuyuki; Hataya, Hiroshi; Kobayashi, Ken; Ikegami, Masahiro; Sotome, Akihiro; Nagai, Yayoi; Kameyama, Kaori; Ishiko, Akira.

In: American Journal of Dermatopathology, Vol. 33, No. 3, 05.2011, p. 271-276.

Research output: Contribution to journalArticle

Miyamoto, Julia ; Tanikawa, Akiko ; Igarashi, Atsuyuki ; Hataya, Hiroshi ; Kobayashi, Ken ; Ikegami, Masahiro ; Sotome, Akihiro ; Nagai, Yayoi ; Kameyama, Kaori ; Ishiko, Akira. / Detection of iron deposition in dermal fibrocytes is a useful tool for histologic diagnosis of nephrogenic systemic fibrosis. In: American Journal of Dermatopathology. 2011 ; Vol. 33, No. 3. pp. 271-276.
@article{417326019ac64db4a4f0dd19956a871e,
title = "Detection of iron deposition in dermal fibrocytes is a useful tool for histologic diagnosis of nephrogenic systemic fibrosis",
abstract = "Nephrogenic systemic fibrosis (NSF) is a fibrotic disease that presents with a history of renal dysfunction. The differential diagnosis generally includes scleromyxedema, systemic sclerosis, and morphea. Especially, scleromyxedema can be extremely difficult to distinguish microscopically. Although the fibrocytes in NSF are often positive for CD34 and procollagen-I, this is not specific for NSF. We identified positive iron staining in the skin of a patient with NSF and investigated whether this was a specific feature among 9 patients with NSF reported in Japan. We found that 6 of 9 patients showed positive iron staining in the dermal fibrocytes. The amount of iron deposition seemed to have no correlation with the degree of fibrosis or duration of the skin lesions but correlated with apparent history of the use of gadolinium-based contrast agents. As controls, skin biopsies from patients with scleromyxedema, morphea, and systemic sclerosis were evaluated by iron staining. None of these control patients showed iron deposition, indicating that positive iron staining may be specific to NSF and can be a useful tool for NSF diagnosis.",
keywords = "gadolinium, iron, magnetic resonance imaging, nephrogenic fibrosing dermopathy, renal insufficiency",
author = "Julia Miyamoto and Akiko Tanikawa and Atsuyuki Igarashi and Hiroshi Hataya and Ken Kobayashi and Masahiro Ikegami and Akihiro Sotome and Yayoi Nagai and Kaori Kameyama and Akira Ishiko",
year = "2011",
month = "5",
doi = "10.1097/DAD.0b013e3181f63eb1",
language = "English",
volume = "33",
pages = "271--276",
journal = "American Journal of Dermatopathology",
issn = "0193-1091",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Detection of iron deposition in dermal fibrocytes is a useful tool for histologic diagnosis of nephrogenic systemic fibrosis

AU - Miyamoto, Julia

AU - Tanikawa, Akiko

AU - Igarashi, Atsuyuki

AU - Hataya, Hiroshi

AU - Kobayashi, Ken

AU - Ikegami, Masahiro

AU - Sotome, Akihiro

AU - Nagai, Yayoi

AU - Kameyama, Kaori

AU - Ishiko, Akira

PY - 2011/5

Y1 - 2011/5

N2 - Nephrogenic systemic fibrosis (NSF) is a fibrotic disease that presents with a history of renal dysfunction. The differential diagnosis generally includes scleromyxedema, systemic sclerosis, and morphea. Especially, scleromyxedema can be extremely difficult to distinguish microscopically. Although the fibrocytes in NSF are often positive for CD34 and procollagen-I, this is not specific for NSF. We identified positive iron staining in the skin of a patient with NSF and investigated whether this was a specific feature among 9 patients with NSF reported in Japan. We found that 6 of 9 patients showed positive iron staining in the dermal fibrocytes. The amount of iron deposition seemed to have no correlation with the degree of fibrosis or duration of the skin lesions but correlated with apparent history of the use of gadolinium-based contrast agents. As controls, skin biopsies from patients with scleromyxedema, morphea, and systemic sclerosis were evaluated by iron staining. None of these control patients showed iron deposition, indicating that positive iron staining may be specific to NSF and can be a useful tool for NSF diagnosis.

AB - Nephrogenic systemic fibrosis (NSF) is a fibrotic disease that presents with a history of renal dysfunction. The differential diagnosis generally includes scleromyxedema, systemic sclerosis, and morphea. Especially, scleromyxedema can be extremely difficult to distinguish microscopically. Although the fibrocytes in NSF are often positive for CD34 and procollagen-I, this is not specific for NSF. We identified positive iron staining in the skin of a patient with NSF and investigated whether this was a specific feature among 9 patients with NSF reported in Japan. We found that 6 of 9 patients showed positive iron staining in the dermal fibrocytes. The amount of iron deposition seemed to have no correlation with the degree of fibrosis or duration of the skin lesions but correlated with apparent history of the use of gadolinium-based contrast agents. As controls, skin biopsies from patients with scleromyxedema, morphea, and systemic sclerosis were evaluated by iron staining. None of these control patients showed iron deposition, indicating that positive iron staining may be specific to NSF and can be a useful tool for NSF diagnosis.

KW - gadolinium

KW - iron

KW - magnetic resonance imaging

KW - nephrogenic fibrosing dermopathy

KW - renal insufficiency

UR - http://www.scopus.com/inward/record.url?scp=79955521877&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955521877&partnerID=8YFLogxK

U2 - 10.1097/DAD.0b013e3181f63eb1

DO - 10.1097/DAD.0b013e3181f63eb1

M3 - Article

C2 - 21389836

AN - SCOPUS:79955521877

VL - 33

SP - 271

EP - 276

JO - American Journal of Dermatopathology

JF - American Journal of Dermatopathology

SN - 0193-1091

IS - 3

ER -