Detection of metastatic medullary thyroid cancer with 131I-MIBG scans in Sipple's syndrome

Hiroshi Itoh; Katsuji Sugie; Shigetake Toyooka; Mitsuo Kawase; Sakae Mukaino; Fumitada Hazama; Keigo Endo; Kanji Torizuka; Kazuwa Nakao; Hiroo Imura

doi:10.1007/BF00252798

Detection of metastatic medullary thyroid cancer with ¹³¹I-MIBG scans in Sipple's syndrome

Hiroshi Itoh, Katsuji Sugie, Shigetake Toyooka, Mitsuo Kawase, Sakae Mukaino, Fumitada Hazama, Keigo Endo, Kanji Torizuka, Kazuwa Nakao, Hiroo Imura

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

While ¹³¹I-meta-iodobenzyl guanidine (¹³¹I-MIBG) scanning has made possible the scintigraphic visualization of pheochromocytoma and neuroblastoma, an accumulation of this agent has recently been reported in medullary thyroid cancer. We present the case of a patient with Sipple's syndrome (multiple endocrine neoplasia type IIa), in whom we were able to identify distant metastases and local invasion of medullary thyroid cancer as well as primary thyroid tumour and right adrenal pheochromocytoma, using ¹³¹I-MIBG scans. This case highlights the usefulness of ¹³¹I-MIBG in the detection of metastatic medullary thyroid cancer and suggests that this agent may also be of therapeutic use in the treatment of tumours.

Original language	English
Pages (from-to)	502-504
Number of pages	3
Journal	European Journal of Nuclear Medicine
Volume	11
Issue number	12
DOIs	https://doi.org/10.1007/BF00252798
Publication status	Published - 1986 Apr 1
Externally published	Yes

Keywords

I-MIGBG scans
MEA IIa
Medullary thyroid cancer
Pheochromocytoma
Sipple's syndrome

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/BF00252798

Cite this

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title = "Detection of metastatic medullary thyroid cancer with 131I-MIBG scans in Sipple's syndrome",

abstract = "While 131I-meta-iodobenzyl guanidine (131I-MIBG) scanning has made possible the scintigraphic visualization of pheochromocytoma and neuroblastoma, an accumulation of this agent has recently been reported in medullary thyroid cancer. We present the case of a patient with Sipple's syndrome (multiple endocrine neoplasia type IIa), in whom we were able to identify distant metastases and local invasion of medullary thyroid cancer as well as primary thyroid tumour and right adrenal pheochromocytoma, using 131I-MIBG scans. This case highlights the usefulness of 131I-MIBG in the detection of metastatic medullary thyroid cancer and suggests that this agent may also be of therapeutic use in the treatment of tumours.",

keywords = "I-MIGBG scans, MEA IIa, Medullary thyroid cancer, Pheochromocytoma, Sipple's syndrome",

author = "Hiroshi Itoh and Katsuji Sugie and Shigetake Toyooka and Mitsuo Kawase and Sakae Mukaino and Fumitada Hazama and Keigo Endo and Kanji Torizuka and Kazuwa Nakao and Hiroo Imura",

year = "1986",

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doi = "10.1007/BF00252798",

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TY - JOUR

T1 - Detection of metastatic medullary thyroid cancer with 131I-MIBG scans in Sipple's syndrome

AU - Itoh, Hiroshi

AU - Sugie, Katsuji

AU - Toyooka, Shigetake

AU - Kawase, Mitsuo

AU - Mukaino, Sakae

AU - Hazama, Fumitada

AU - Endo, Keigo

AU - Torizuka, Kanji

AU - Nakao, Kazuwa

AU - Imura, Hiroo

PY - 1986/4/1

Y1 - 1986/4/1

N2 - While 131I-meta-iodobenzyl guanidine (131I-MIBG) scanning has made possible the scintigraphic visualization of pheochromocytoma and neuroblastoma, an accumulation of this agent has recently been reported in medullary thyroid cancer. We present the case of a patient with Sipple's syndrome (multiple endocrine neoplasia type IIa), in whom we were able to identify distant metastases and local invasion of medullary thyroid cancer as well as primary thyroid tumour and right adrenal pheochromocytoma, using 131I-MIBG scans. This case highlights the usefulness of 131I-MIBG in the detection of metastatic medullary thyroid cancer and suggests that this agent may also be of therapeutic use in the treatment of tumours.

AB - While 131I-meta-iodobenzyl guanidine (131I-MIBG) scanning has made possible the scintigraphic visualization of pheochromocytoma and neuroblastoma, an accumulation of this agent has recently been reported in medullary thyroid cancer. We present the case of a patient with Sipple's syndrome (multiple endocrine neoplasia type IIa), in whom we were able to identify distant metastases and local invasion of medullary thyroid cancer as well as primary thyroid tumour and right adrenal pheochromocytoma, using 131I-MIBG scans. This case highlights the usefulness of 131I-MIBG in the detection of metastatic medullary thyroid cancer and suggests that this agent may also be of therapeutic use in the treatment of tumours.

KW - I-MIGBG scans

KW - MEA IIa

KW - Medullary thyroid cancer

KW - Pheochromocytoma

KW - Sipple's syndrome

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