Abstract
We have examined the expression of P-glycoprotein in clinical leukemic cell samples by using a monoclonal antibody (MRK16) against P-glycoprotein. We found that leukemia cells isolated from 3 out of 6 patients with blast crisis of chronic myelogenous leukemia were reactive to MRK16. These 3 cell lines expressed high levels of mdrl mRNA, which codes for P-glycoprotein. The present result indicates that the clinically refractory state of the tumor may be predicted in part by determining P-glycoprotein expression using the monoclonal antibody against P-glycoprotein, and the mdrl probe.
| Original language | English |
|---|---|
| Pages (from-to) | 1415-1419 |
| Number of pages | 5 |
| Journal | Japanese Journal of Cancer Research GANN |
| Volume | 78 |
| Issue number | 12 |
| Publication status | Published - 1987 |
| Externally published | Yes |
Keywords
- Drug resistance
- Drug resistance gene
- Gene amplification
- Gene expression
ASJC Scopus subject areas
- Oncology
- Cancer Research
