Detection of pre-charring optical behavior at a laser catheter-tip in blood: Ex vivo and in vivo study

Mei Takahashi, Arisa Ito, Takuro Kajihara, Tsunenori Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We studied a pre-charring optical behavior of blood at a laser catheter-tip during a red laser irradiation (663 nm, CW) with around 50 W/cm2 in blood to prevent charring at the laser catheter-tip. The laser irradiated red-blood-cell shape changes were microscopically observed. A round formation, aggregation, and hemolysis were found until blood charring (ex vivo). A time-history of diffuse-reflected light power and transmitted light power from a thin blood layer which was irradiated by the red laser were measured with microscope optics to investigate the charring process. The diffusereflected light power decreased following a gentle peak before the charring. This decrease indicated the pre-charring behavior which might be induced by scattering and absorption changes due to red-blood-cell degenerations described above. Using the laser catheter located in porcine heart, we successfully detected the pre-charring behavior by a backscattering light power (in vivo). We demonstrated charring prevention availability with the laser power control (ex vivo). We think that the backscattering light power measurement and laser power control via the laser catheter might be useful to detect pre-charring behavior, and to prevent the charring for therapeutic laser irradiation in blood under catheterization such as arrhythmia treatment with photodynamic therapy.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7897
DOIs
Publication statusPublished - 2011
EventOptical Interactions with Tissue and Cells XXII - San Francisco, CA, United States
Duration: 2011 Jan 242011 Jan 26

Other

OtherOptical Interactions with Tissue and Cells XXII
CountryUnited States
CitySan Francisco, CA
Period11/1/2411/1/26

Fingerprint

charring
Catheters
blood
Lasers
Blood
lasers
Light
Laser beam effects
Backscattering
Power control
erythrocytes
backscattering
Photodynamic therapy
Erythrocytes
catheterization
hemolysis
arrhythmia
irradiation
degeneration
Cell Shape

Keywords

  • Blood charring
  • Charring prevention
  • Laser irradiation
  • Pre-charring detection

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Takahashi, M., Ito, A., Kajihara, T., & Arai, T. (2011). Detection of pre-charring optical behavior at a laser catheter-tip in blood: Ex vivo and in vivo study. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7897). [78970U] https://doi.org/10.1117/12.874622

Detection of pre-charring optical behavior at a laser catheter-tip in blood : Ex vivo and in vivo study. / Takahashi, Mei; Ito, Arisa; Kajihara, Takuro; Arai, Tsunenori.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7897 2011. 78970U.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Takahashi, M, Ito, A, Kajihara, T & Arai, T 2011, Detection of pre-charring optical behavior at a laser catheter-tip in blood: Ex vivo and in vivo study. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7897, 78970U, Optical Interactions with Tissue and Cells XXII, San Francisco, CA, United States, 11/1/24. https://doi.org/10.1117/12.874622
Takahashi M, Ito A, Kajihara T, Arai T. Detection of pre-charring optical behavior at a laser catheter-tip in blood: Ex vivo and in vivo study. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7897. 2011. 78970U https://doi.org/10.1117/12.874622
Takahashi, Mei ; Ito, Arisa ; Kajihara, Takuro ; Arai, Tsunenori. / Detection of pre-charring optical behavior at a laser catheter-tip in blood : Ex vivo and in vivo study. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7897 2011.
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