Detection of unsuspected distant metastases and/or regional nodes by FDG-PET in LD-SCLC scan in apparent limited-disease small-cell lung cancer

Seiji Niho, Hirofumi Fujii, Koji Murakami, Seisuke Nagase, Kiyotaka Yoh, Koichi Goto, Hironobu Ohmatsu, Kaoru Kubota, Ryuzo Sekiguchi, Shigeru Nawano, Nagahiro Saijo, Yutaka Nishiwaki

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Abstract

We retrospectively investigated the clinical usefulness of fluorodeoxyglucose positron emission tomography (FDG-PET) for evaluation of patients with limited-disease small-cell lung cancer (LD-SCLC) diagnosed by conventional staging procedures. Sixty-three patients received whole body FDG-PET scans after routine initial staging procedures. The findings of FDG-PET scans suggesting extensive-stage disease were confirmed by other imaging tests or by the patient's clinical course. FDG-PET scan findings indicated distant metastases in 6 of 63 patients. Metastatic disease was confirmed in five of these six patients (8%, 95% confidence interval: 3-18%). FDG-PET scan also detected regional lymph node metastases even in nine patients (14%) in whom computed tomography images had been negative, including contralateral lymph node metastasis in three patients. FDG-PET scan detected additional lesions in patients diagnosed as having LD-SCLC by conventional staging procedures. The therapeutic strategies were changed in 8% of patients based on the results of FDG-PET. FDG-PET scan is recommended as an initial staging tool for patients with this disease.

Original languageEnglish
Pages (from-to)328-333
Number of pages6
JournalLung Cancer
Volume57
Issue number3
DOIs
Publication statusPublished - 2007 Sep

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Keywords

  • CT
  • FDG-PET
  • Limited-disease
  • Occult distant metastasis
  • Small-cell lung cancer
  • Staging

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Niho, S., Fujii, H., Murakami, K., Nagase, S., Yoh, K., Goto, K., Ohmatsu, H., Kubota, K., Sekiguchi, R., Nawano, S., Saijo, N., & Nishiwaki, Y. (2007). Detection of unsuspected distant metastases and/or regional nodes by FDG-PET in LD-SCLC scan in apparent limited-disease small-cell lung cancer. Lung Cancer, 57(3), 328-333. https://doi.org/10.1016/j.lungcan.2007.04.001