Detection of unsuspected distant metastases and/or regional nodes by FDG-PET in LD-SCLC scan in apparent limited-disease small-cell lung cancer

Seiji Niho, Hirofumi Fujii, Koji Murakami, Seisuke Nagase, Kiyotaka Yoh, Koichi Goto, Hironobu Ohmatsu, Kaoru Kubota, Ryuzo Sekiguchi, Shigeru Nawano, Nagahiro Saijo, Yutaka Nishiwaki

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

We retrospectively investigated the clinical usefulness of fluorodeoxyglucose positron emission tomography (FDG-PET) for evaluation of patients with limited-disease small-cell lung cancer (LD-SCLC) diagnosed by conventional staging procedures. Sixty-three patients received whole body FDG-PET scans after routine initial staging procedures. The findings of FDG-PET scans suggesting extensive-stage disease were confirmed by other imaging tests or by the patient's clinical course. FDG-PET scan findings indicated distant metastases in 6 of 63 patients. Metastatic disease was confirmed in five of these six patients (8%, 95% confidence interval: 3-18%). FDG-PET scan also detected regional lymph node metastases even in nine patients (14%) in whom computed tomography images had been negative, including contralateral lymph node metastasis in three patients. FDG-PET scan detected additional lesions in patients diagnosed as having LD-SCLC by conventional staging procedures. The therapeutic strategies were changed in 8% of patients based on the results of FDG-PET. FDG-PET scan is recommended as an initial staging tool for patients with this disease.

Original languageEnglish
Pages (from-to)328-333
Number of pages6
JournalLung Cancer
Volume57
Issue number3
DOIs
Publication statusPublished - 2007 Sep
Externally publishedYes

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Small Cell Lung Carcinoma
Positron-Emission Tomography
Neoplasm Metastasis
Lymph Nodes
Neoplasm Staging
Tomography
Confidence Intervals

Keywords

  • CT
  • FDG-PET
  • Limited-disease
  • Occult distant metastasis
  • Small-cell lung cancer
  • Staging

ASJC Scopus subject areas

  • Oncology

Cite this

Detection of unsuspected distant metastases and/or regional nodes by FDG-PET in LD-SCLC scan in apparent limited-disease small-cell lung cancer. / Niho, Seiji; Fujii, Hirofumi; Murakami, Koji; Nagase, Seisuke; Yoh, Kiyotaka; Goto, Koichi; Ohmatsu, Hironobu; Kubota, Kaoru; Sekiguchi, Ryuzo; Nawano, Shigeru; Saijo, Nagahiro; Nishiwaki, Yutaka.

In: Lung Cancer, Vol. 57, No. 3, 09.2007, p. 328-333.

Research output: Contribution to journalArticle

Niho, S, Fujii, H, Murakami, K, Nagase, S, Yoh, K, Goto, K, Ohmatsu, H, Kubota, K, Sekiguchi, R, Nawano, S, Saijo, N & Nishiwaki, Y 2007, 'Detection of unsuspected distant metastases and/or regional nodes by FDG-PET in LD-SCLC scan in apparent limited-disease small-cell lung cancer', Lung Cancer, vol. 57, no. 3, pp. 328-333. https://doi.org/10.1016/j.lungcan.2007.04.001
Niho, Seiji ; Fujii, Hirofumi ; Murakami, Koji ; Nagase, Seisuke ; Yoh, Kiyotaka ; Goto, Koichi ; Ohmatsu, Hironobu ; Kubota, Kaoru ; Sekiguchi, Ryuzo ; Nawano, Shigeru ; Saijo, Nagahiro ; Nishiwaki, Yutaka. / Detection of unsuspected distant metastases and/or regional nodes by FDG-PET in LD-SCLC scan in apparent limited-disease small-cell lung cancer. In: Lung Cancer. 2007 ; Vol. 57, No. 3. pp. 328-333.
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