Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders

Yoshiyasu Aoki, Robert Yarchoan, Kathleen Wyvill, Shinichiro Okamoto, Richard F. Little, Giovanna Tosato

Research output: Contribution to journalArticle

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Abstract

Expression of a viral interleukin-6 (vIL-6) has been detected in certain Kaposi sarcoma (KS)-associated herpesvirus positive (KSHV+) lesions. The release of vIL-6 systemically and its contribution to the pathogenesis of HIV-related malignancies was studied. Serum vIL-6 was detected in 13 (38.2%) of 34 HIV+ patients with KS, in 6 (85.7%) of 7 HIV+ patients with primary effusion lymphoma (PEL) and/or multicentric Castleman disease (MCD), and in 18 (60.0%) of 30 HIV+, mostly homosexual, individuals without KS, MCD, or PEL. By contrast, serum vIL-6 was detected in only 3 (23.1%) of 13 patients with classic KS, 1 (2.5%) of 40 blood donors from the United States, and 4 (19.0%) of 21 blood donors from Italy. Circulating vIL-6 levels were associated with HIV+ status (P<.0001). However, within the HIV+ cohort, serum vIL-6 levels were not associated with the occurrence of KSHV-associated malignancies (P = .43).

Original languageEnglish
Pages (from-to)2173-2176
Number of pages4
JournalBlood
Volume97
Issue number7
DOIs
Publication statusPublished - 2001 Apr 1
Externally publishedYes

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Human Herpesvirus 8
Interleukin-6
HIV
Kaposi's Sarcoma
Primary Effusion Lymphoma
Blood Donors
Blood
Serum
Italy
Neoplasms

ASJC Scopus subject areas

  • Hematology

Cite this

Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders. / Aoki, Yoshiyasu; Yarchoan, Robert; Wyvill, Kathleen; Okamoto, Shinichiro; Little, Richard F.; Tosato, Giovanna.

In: Blood, Vol. 97, No. 7, 01.04.2001, p. 2173-2176.

Research output: Contribution to journalArticle

Aoki, Y, Yarchoan, R, Wyvill, K, Okamoto, S, Little, RF & Tosato, G 2001, 'Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders', Blood, vol. 97, no. 7, pp. 2173-2176. https://doi.org/10.1182/blood.V97.7.2173
Aoki, Yoshiyasu ; Yarchoan, Robert ; Wyvill, Kathleen ; Okamoto, Shinichiro ; Little, Richard F. ; Tosato, Giovanna. / Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders. In: Blood. 2001 ; Vol. 97, No. 7. pp. 2173-2176.
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