TY - JOUR
T1 - Determinants of chronic obstructive pulmonary disease severity in the late-elderly differ from those in younger patients Pulmonary Medicine
AU - Haraguchi, Mizuha
AU - Nakamura, Hidetoshi
AU - Sasaki, Mamoru
AU - Miyazaki, Masaki
AU - Chubachi, Shotaro
AU - Takahashi, Saeko
AU - Asano, Koichiro
AU - Jones, Paul W.
AU - Betsuyaku, Tomoko
N1 - Funding Information:
TB discloses having received honoraria/paid expert testimony and her university having received research grants from GlaxoSmithKline. PWJ discloses that his university has received honoraria and research grants from GlaxoSmith-Kline. The other authors declare that they have no competing interests.
Funding Information:
We thank Chiyomi Uemura for her contribution to the collection of data. This study was funded by GlaxoSmithKline. We also thank the following members for their participation in the Keio COPD Comorbidity Research (K-CCR) group: Hidefumi Koh (Saiseikai Utsunomiya Hospital), Fumio Sakamaki (Tokyo Saiseikai Central Hospital), Takeshi Terashima and Tatsu Matsuzaki (Department of Respiratory Medicine, Tokyo Dental College), Morio Nakamura and Keishi Tsuduki (Eiju General Hospital), Naoto Min-ematsu (Hino City Hospital), Koichi Sayama (Kawasaki City Hospital), Takashi Inoue (Sano Public Welfare General Hospital), Naoki Miyao (Nihon Kokan Hospital), Kazumi Nishio (Kawasaki City Ida Hospital), Hiroki Tateno (Saitama City Hospital), Yoshitaka Oyamada and Shuichi Yoshida (Tokyo Medical Center), Toru Shirahata (Saitama Medical Center), Akira Umeda (International Medical Welfare College Shioya Hospital).
Publisher Copyright:
© 2015 Haraguchi et al.
PY - 2016/1/4
Y1 - 2016/1/4
N2 - Background: Although the age range of chronic obstructive pulmonary disease (COPD) patients is broad, few studies have focused on the effects of age on disease characteristics. Methods: Keio University and affiliated hospitals established an observational COPD cohort. Patients were assessed using high resolution computed tomography (CT) to quantify emphysema, health status using the COPD assessment test (CAT) and the St. George's Respiratory Questionnaire (SGRQ), spirometry, echocardiogram, dual X-ray absorption of bone, biomarkers and comorbid diagnoses. We examined the characteristics of COPD patients aged 75 and over compared with patients below 75. Results: A total of 443 patients comprising 252 patients aged <75 years and 191 patients aged ≥75 years, were enrolled. Emphysematous changes on CT and prevalence of possible pulmonary hypertension were greater in late-elderly patients. The slope of the relationship between CT emphysema densitometry score and forced expiratory volume in 1 s was significantly less steep in the late-elderly than the younger patients (p = 0.002). CAT and total SGRQ scores and the frequency of long-term oxygen therapy were significantly higher in the late-elderly with moderate airflow obstruction compared to those of the younger in the same grade, although the opposite was seen in late-elderly patients with very severe airflow obstruction. Hypertension, aortic aneurysm, prostatic hypertrophy, anemia, and cataract are more prevalent in late-elderly patients. Conclusions: Elderly COPD patients show a varied age-related pattern of disease that warrants specific attention in clinical practice above and beyond assessment of airflow limitation. Trial registration Clinical trial registered with the University Hospital Medical Information Network (UMIN000003470, April 10, 2010).
AB - Background: Although the age range of chronic obstructive pulmonary disease (COPD) patients is broad, few studies have focused on the effects of age on disease characteristics. Methods: Keio University and affiliated hospitals established an observational COPD cohort. Patients were assessed using high resolution computed tomography (CT) to quantify emphysema, health status using the COPD assessment test (CAT) and the St. George's Respiratory Questionnaire (SGRQ), spirometry, echocardiogram, dual X-ray absorption of bone, biomarkers and comorbid diagnoses. We examined the characteristics of COPD patients aged 75 and over compared with patients below 75. Results: A total of 443 patients comprising 252 patients aged <75 years and 191 patients aged ≥75 years, were enrolled. Emphysematous changes on CT and prevalence of possible pulmonary hypertension were greater in late-elderly patients. The slope of the relationship between CT emphysema densitometry score and forced expiratory volume in 1 s was significantly less steep in the late-elderly than the younger patients (p = 0.002). CAT and total SGRQ scores and the frequency of long-term oxygen therapy were significantly higher in the late-elderly with moderate airflow obstruction compared to those of the younger in the same grade, although the opposite was seen in late-elderly patients with very severe airflow obstruction. Hypertension, aortic aneurysm, prostatic hypertrophy, anemia, and cataract are more prevalent in late-elderly patients. Conclusions: Elderly COPD patients show a varied age-related pattern of disease that warrants specific attention in clinical practice above and beyond assessment of airflow limitation. Trial registration Clinical trial registered with the University Hospital Medical Information Network (UMIN000003470, April 10, 2010).
KW - Chronic obstructive pulmonary disease
KW - Comorbidity
KW - Elderly
KW - Emphysema
KW - Symptom
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U2 - 10.1186/s13104-015-1810-8
DO - 10.1186/s13104-015-1810-8
M3 - Article
C2 - 26728686
AN - SCOPUS:84953331339
SN - 1756-0500
VL - 9
JO - BMC Research Notes
JF - BMC Research Notes
IS - 1
M1 - 7
ER -