Determinants of normal and increased microvessel permeability

Fitz Roy E. Curry, Roger H. Adamson, Bing Mei Fu, Ping He, Joyce F. Lenz, Mayumi Kajimura, Stamatis N. Pagakis, Sheldon Weinbaum

Research output: Contribution to conferencePaper

Abstract

The molecular structures which determine the normal permeability properties of the capillary wall and modulate changes in microvessel permeability include the cell surface glycocalyx, the junctional strands in the cleft between the adjacent endothelial cells, and the endothelial cell attachment sites to the extracellular matrix. To evaluate the role of the glycocalyx and junctional strand geometry as determinants of normal permeability properties, a 3D model was developed for water and solute flow through the cleft between the adjacent cells. To identify the very small pore pathway, a time-dependent diffusion model was developed for analysis of concentration profiles of electron dense small tracers in the interendothelial clefts.

Original languageEnglish
Pages71-72
Number of pages2
Publication statusPublished - 1995 Jan 1
Externally publishedYes
EventProceedings of the 1995 Bioengineering Conference - Beever Creek, CO, USA
Duration: 1995 Jun 281995 Jul 2

Other

OtherProceedings of the 1995 Bioengineering Conference
CityBeever Creek, CO, USA
Period95/6/2895/7/2

ASJC Scopus subject areas

  • Engineering(all)

Fingerprint Dive into the research topics of 'Determinants of normal and increased microvessel permeability'. Together they form a unique fingerprint.

  • Cite this

    Curry, F. R. E., Adamson, R. H., Fu, B. M., He, P., Lenz, J. F., Kajimura, M., Pagakis, S. N., & Weinbaum, S. (1995). Determinants of normal and increased microvessel permeability. 71-72. Paper presented at Proceedings of the 1995 Bioengineering Conference, Beever Creek, CO, USA, .