Determinants of normal and increased microvessel permeability

Fitz Roy E Curry, Roger H. Adamson, Bing Mei Fu, Ping He, Joyce F. Lenz, Mayumi Kajimura, Stamatis N. Pagakis, Sheldon Weinbaum

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The molecular structures which determine the normal permeability properties of the capillary wall and modulate changes in microvessel permeability include the cell surface glycocalyx, the junctional strands in the cleft between the adjacent endothelial cells, and the endothelial cell attachment sites to the extracellular matrix. To evaluate the role of the glycocalyx and junctional strand geometry as determinants of normal permeability properties, a 3D model was developed for water and solute flow through the cleft between the adjacent cells. To identify the very small pore pathway, a time-dependent diffusion model was developed for analysis of concentration profiles of electron dense small tracers in the interendothelial clefts.

Original languageEnglish
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages71-72
Number of pages2
Volume29
Publication statusPublished - 1995
Externally publishedYes
EventProceedings of the 1995 Bioengineering Conference - Beever Creek, CO, USA
Duration: 1995 Jun 281995 Jul 2

Other

OtherProceedings of the 1995 Bioengineering Conference
CityBeever Creek, CO, USA
Period95/6/2895/7/2

Fingerprint

Endothelial cells
Molecular structure
Geometry
Electrons
Water

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Curry, F. R. E., Adamson, R. H., Fu, B. M., He, P., Lenz, J. F., Kajimura, M., ... Weinbaum, S. (1995). Determinants of normal and increased microvessel permeability. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 29, pp. 71-72). ASME.

Determinants of normal and increased microvessel permeability. / Curry, Fitz Roy E; Adamson, Roger H.; Fu, Bing Mei; He, Ping; Lenz, Joyce F.; Kajimura, Mayumi; Pagakis, Stamatis N.; Weinbaum, Sheldon.

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 29 ASME, 1995. p. 71-72.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Curry, FRE, Adamson, RH, Fu, BM, He, P, Lenz, JF, Kajimura, M, Pagakis, SN & Weinbaum, S 1995, Determinants of normal and increased microvessel permeability. in American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 29, ASME, pp. 71-72, Proceedings of the 1995 Bioengineering Conference, Beever Creek, CO, USA, 95/6/28.
Curry FRE, Adamson RH, Fu BM, He P, Lenz JF, Kajimura M et al. Determinants of normal and increased microvessel permeability. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 29. ASME. 1995. p. 71-72
Curry, Fitz Roy E ; Adamson, Roger H. ; Fu, Bing Mei ; He, Ping ; Lenz, Joyce F. ; Kajimura, Mayumi ; Pagakis, Stamatis N. ; Weinbaum, Sheldon. / Determinants of normal and increased microvessel permeability. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 29 ASME, 1995. pp. 71-72
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