Determination of medetomidine, atipamezole and midazolam in pig plasma by liquid chromatography-mass spectrometry

Hideko Kanazawa, R. Nishimura, N. Sasaki, A. Takeuchi, N. Takai, Yoshiko Itoh, Y. Matsushima

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Medetomidine, atipamezole and midazolam in pig plasma were determined by liquid chromatography-mass spectrometry (LC-MS) with an atmospheric pressure chemical ionization interface system by the use of detomidine as an internal standard, The method was applied to studies of pharmacokinetic behaviour of these drugs.

Original languageEnglish
Pages (from-to)188-191
Number of pages4
JournalBiomedical Chromatography
Volume9
Issue number4
DOIs
Publication statusPublished - 1995

Fingerprint

Medetomidine
Atmospheric Pressure
Pharmacokinetics
Midazolam
Liquid chromatography
Liquid Chromatography
Atmospheric pressure
Ionization
Mass spectrometry
Mass Spectrometry
Swine
Plasmas
Pharmaceutical Preparations
detomidine
atipamezole

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology

Cite this

Determination of medetomidine, atipamezole and midazolam in pig plasma by liquid chromatography-mass spectrometry. / Kanazawa, Hideko; Nishimura, R.; Sasaki, N.; Takeuchi, A.; Takai, N.; Itoh, Yoshiko; Matsushima, Y.

In: Biomedical Chromatography, Vol. 9, No. 4, 1995, p. 188-191.

Research output: Contribution to journalArticle

Kanazawa, Hideko ; Nishimura, R. ; Sasaki, N. ; Takeuchi, A. ; Takai, N. ; Itoh, Yoshiko ; Matsushima, Y. / Determination of medetomidine, atipamezole and midazolam in pig plasma by liquid chromatography-mass spectrometry. In: Biomedical Chromatography. 1995 ; Vol. 9, No. 4. pp. 188-191.
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