Development and biological evaluation of apatite fibre scaffolds with large pore size and high porosity for bone regeneration

Mamoru Aizawa, Hiroki Shinoda, Hiroshi Uchida, Kiyoshi Itatani, Isao Okada, Morio Matsumoto, Hikaru Morisue, Hideo Matsumoto, Yoshiaki Toyama

Research output: Contribution to journalConference article

12 Citations (Scopus)

Abstract

Novel scaffolds have been developed from single-crystal apatite fibres synthesized by a homogeneous precipitation method using urea. The resulting apatite fibre scaffolds have large pores with diameters of 110-250 μm and high porosities of 98-99%. The scaffolds were biologically evaluated using two kinds of cells, osteoblast cells (MC3T3-E1) and rat bone marrow cells. In both cases, the cells cultured in the scaffolds showed excellent cellular response, such as good cell proliferation and enhanced differentiation into osteoblasts. We conclude that such scaffolds with high porosity and large pore size may be effective as the matrix of tissue engineered structures in order to promote regeneration of bone.

Original languageEnglish
Pages (from-to)647-650
Number of pages4
JournalKey Engineering Materials
Volume240-242
Publication statusPublished - 2003 Apr 21
EventProceedings of the 15th International Symposium on Ceramics in Medicine; The Annual Meeting of the International Society for Ceramics in Medicine - Sydney, NSW, Australia
Duration: 2002 Dec 42002 Dec 8

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Keywords

  • Bone marrow cell
  • Bone regeneration
  • Hydroxyapatite
  • In vitro evaluation
  • Osteoblast
  • Scaffold
  • Single-crystal fibre
  • Tissue engineering

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Aizawa, M., Shinoda, H., Uchida, H., Itatani, K., Okada, I., Matsumoto, M., Morisue, H., Matsumoto, H., & Toyama, Y. (2003). Development and biological evaluation of apatite fibre scaffolds with large pore size and high porosity for bone regeneration. Key Engineering Materials, 240-242, 647-650.