Abstract
Novel scaffolds have been developed from single-crystal apatite fibres synthesized by a homogeneous precipitation method using urea. The resulting apatite fibre scaffolds have large pores with diameters of 110-250 μm and high porosities of 98-99%. The scaffolds were biologically evaluated using two kinds of cells, osteoblast cells (MC3T3-E1) and rat bone marrow cells. In both cases, the cells cultured in the scaffolds showed excellent cellular response, such as good cell proliferation and enhanced differentiation into osteoblasts. We conclude that such scaffolds with high porosity and large pore size may be effective as the matrix of tissue engineered structures in order to promote regeneration of bone.
| Original language | English |
|---|---|
| Pages (from-to) | 647-650 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 240-242 |
| Publication status | Published - 2003 |
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Keywords
- Bone marrow cell
- Bone regeneration
- Hydroxyapatite
- In vitro evaluation
- Osteoblast
- Scaffold
- Single-crystal fibre
- Tissue engineering
ASJC Scopus subject areas
- Ceramics and Composites
- Chemical Engineering (miscellaneous)
Cite this
Development and biological evaluation of apatite fibre scaffolds with large pore size and high porosity for bone regeneration. / Aizawa, Mamoru; Shinoda, Hiroki; Uchida, Hiroshi; Itatani, Kiyoshi; Okada, Isao; Matsumoto, Morio; Morisue, Hikaru; Matsumoto, Hideo; Toyama, Yoshiaki.
In: Key Engineering Materials, Vol. 240-242, 2003, p. 647-650.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development and biological evaluation of apatite fibre scaffolds with large pore size and high porosity for bone regeneration
AU - Aizawa, Mamoru
AU - Shinoda, Hiroki
AU - Uchida, Hiroshi
AU - Itatani, Kiyoshi
AU - Okada, Isao
AU - Matsumoto, Morio
AU - Morisue, Hikaru
AU - Matsumoto, Hideo
AU - Toyama, Yoshiaki
PY - 2003
Y1 - 2003
N2 - Novel scaffolds have been developed from single-crystal apatite fibres synthesized by a homogeneous precipitation method using urea. The resulting apatite fibre scaffolds have large pores with diameters of 110-250 μm and high porosities of 98-99%. The scaffolds were biologically evaluated using two kinds of cells, osteoblast cells (MC3T3-E1) and rat bone marrow cells. In both cases, the cells cultured in the scaffolds showed excellent cellular response, such as good cell proliferation and enhanced differentiation into osteoblasts. We conclude that such scaffolds with high porosity and large pore size may be effective as the matrix of tissue engineered structures in order to promote regeneration of bone.
AB - Novel scaffolds have been developed from single-crystal apatite fibres synthesized by a homogeneous precipitation method using urea. The resulting apatite fibre scaffolds have large pores with diameters of 110-250 μm and high porosities of 98-99%. The scaffolds were biologically evaluated using two kinds of cells, osteoblast cells (MC3T3-E1) and rat bone marrow cells. In both cases, the cells cultured in the scaffolds showed excellent cellular response, such as good cell proliferation and enhanced differentiation into osteoblasts. We conclude that such scaffolds with high porosity and large pore size may be effective as the matrix of tissue engineered structures in order to promote regeneration of bone.
KW - Bone marrow cell
KW - Bone regeneration
KW - Hydroxyapatite
KW - In vitro evaluation
KW - Osteoblast
KW - Scaffold
KW - Single-crystal fibre
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=0037247065&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037247065&partnerID=8YFLogxK
M3 - Article
VL - 240-242
SP - 647
EP - 650
JO - Key Engineering Materials
JF - Key Engineering Materials
SN - 1013-9826
ER -