Abstract
Novel scaffolds have been developed from single-crystal apatite fibres synthesized by a homogeneous precipitation method using urea. The resulting apatite fibre scaffolds have large pores with diameters of 110-250 μm and high porosities of 98-99%. The scaffolds were biologically evaluated using two kinds of cells, osteoblast cells (MC3T3-E1) and rat bone marrow cells. In both cases, the cells cultured in the scaffolds showed excellent cellular response, such as good cell proliferation and enhanced differentiation into osteoblasts. We conclude that such scaffolds with high porosity and large pore size may be effective as the matrix of tissue engineered structures in order to promote regeneration of bone.
| Original language | English |
|---|---|
| Pages (from-to) | 647-650 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 240-242 |
| Publication status | Published - 2003 Apr 21 |
| Event | Proceedings of the 15th International Symposium on Ceramics in Medicine; The Annual Meeting of the International Society for Ceramics in Medicine - Sydney, NSW, Australia Duration: 2002 Dec 4 → 2002 Dec 8 |
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Keywords
- Bone marrow cell
- Bone regeneration
- Hydroxyapatite
- In vitro evaluation
- Osteoblast
- Scaffold
- Single-crystal fibre
- Tissue engineering
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
Cite this
Aizawa, M., Shinoda, H., Uchida, H., Itatani, K., Okada, I., Matsumoto, M., Morisue, H., Matsumoto, H., & Toyama, Y. (2003). Development and biological evaluation of apatite fibre scaffolds with large pore size and high porosity for bone regeneration. Key Engineering Materials, 240-242, 647-650.