Development and maintenance of intestinal regulatory T cells

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Gut-resident forkhead box P3 (FOXP3) + CD4 + regulatory T cells (T reg cells) are distinct from those in other organs and have gut-specific phenotypes and functions. Whereas T reg cells in other organs have T cell receptors (TCRs) specific for self antigens, intestinal T reg cells have a distinct set of TCRs that are specific for intestinal antigens, and these cells have pivotal roles in the suppression of immune responses against harmless dietary antigens and commensal microorganisms. The differentiation, migration and maintenance of intestinal T reg cells are controlled by specific signals from the local environment. In particular, certain members of the microbiota continuously provide antigens and immunoregulatory small molecules that modulate intestinal T reg cells. Understanding the development and the maintenance of intestinal T reg cells provides important insights into disease-relevant host-microorganism interactions.

Original languageEnglish
Pages (from-to)295-309
Number of pages15
JournalNature Reviews Immunology
Volume16
Issue number5
DOIs
Publication statusPublished - 2016 Apr 28

Fingerprint

Regulatory T-Lymphocytes
Maintenance
T-Cell Antigen Receptor
Antigens
Microbiota
Autoantigens
Phenotype

ASJC Scopus subject areas

  • Immunology

Cite this

Development and maintenance of intestinal regulatory T cells. / Tanoue, Takeshi; Atarashi, Koji; Honda, Kenya.

In: Nature Reviews Immunology, Vol. 16, No. 5, 28.04.2016, p. 295-309.

Research output: Contribution to journalArticle

@article{8748456c0f264650a1e25dcb34f19fde,
title = "Development and maintenance of intestinal regulatory T cells",
abstract = "Gut-resident forkhead box P3 (FOXP3) + CD4 + regulatory T cells (T reg cells) are distinct from those in other organs and have gut-specific phenotypes and functions. Whereas T reg cells in other organs have T cell receptors (TCRs) specific for self antigens, intestinal T reg cells have a distinct set of TCRs that are specific for intestinal antigens, and these cells have pivotal roles in the suppression of immune responses against harmless dietary antigens and commensal microorganisms. The differentiation, migration and maintenance of intestinal T reg cells are controlled by specific signals from the local environment. In particular, certain members of the microbiota continuously provide antigens and immunoregulatory small molecules that modulate intestinal T reg cells. Understanding the development and the maintenance of intestinal T reg cells provides important insights into disease-relevant host-microorganism interactions.",
author = "Takeshi Tanoue and Koji Atarashi and Kenya Honda",
year = "2016",
month = "4",
day = "28",
doi = "10.1038/nri.2016.36",
language = "English",
volume = "16",
pages = "295--309",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Development and maintenance of intestinal regulatory T cells

AU - Tanoue, Takeshi

AU - Atarashi, Koji

AU - Honda, Kenya

PY - 2016/4/28

Y1 - 2016/4/28

N2 - Gut-resident forkhead box P3 (FOXP3) + CD4 + regulatory T cells (T reg cells) are distinct from those in other organs and have gut-specific phenotypes and functions. Whereas T reg cells in other organs have T cell receptors (TCRs) specific for self antigens, intestinal T reg cells have a distinct set of TCRs that are specific for intestinal antigens, and these cells have pivotal roles in the suppression of immune responses against harmless dietary antigens and commensal microorganisms. The differentiation, migration and maintenance of intestinal T reg cells are controlled by specific signals from the local environment. In particular, certain members of the microbiota continuously provide antigens and immunoregulatory small molecules that modulate intestinal T reg cells. Understanding the development and the maintenance of intestinal T reg cells provides important insights into disease-relevant host-microorganism interactions.

AB - Gut-resident forkhead box P3 (FOXP3) + CD4 + regulatory T cells (T reg cells) are distinct from those in other organs and have gut-specific phenotypes and functions. Whereas T reg cells in other organs have T cell receptors (TCRs) specific for self antigens, intestinal T reg cells have a distinct set of TCRs that are specific for intestinal antigens, and these cells have pivotal roles in the suppression of immune responses against harmless dietary antigens and commensal microorganisms. The differentiation, migration and maintenance of intestinal T reg cells are controlled by specific signals from the local environment. In particular, certain members of the microbiota continuously provide antigens and immunoregulatory small molecules that modulate intestinal T reg cells. Understanding the development and the maintenance of intestinal T reg cells provides important insights into disease-relevant host-microorganism interactions.

UR - http://www.scopus.com/inward/record.url?scp=84964403670&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964403670&partnerID=8YFLogxK

U2 - 10.1038/nri.2016.36

DO - 10.1038/nri.2016.36

M3 - Article

C2 - 27087661

AN - SCOPUS:84964403670

VL - 16

SP - 295

EP - 309

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

IS - 5

ER -