Development and pathological changes of neurovascular unit regulated by hypoxia response in the retina

T. Kurihara

doi:10.1016/bs.pbr.2016.03.006

Development and pathological changes of neurovascular unit regulated by hypoxia response in the retina

T. Kurihara

Department of Ophthalmology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Citations (Scopus)

Abstract

Retina is a highly vascularized tissue with a high oxygen and metabolic demand receiving light located in the back of the eye. The development and the maintenance of the retinal vasculature are important to regulate the homeostasis in the tissue. α Subunits of hypoxia-inducible factor (HIF) are key molecules in hypoxia response inducing genes required for cell survival such as vascular endothelial growth factor under hypoxia. Neurons, glia, and vascular endothelium cells interdependently form neurovascular unit in the retina tightly regulated by hypoxia response via HIF expression. A corruption of the precise hypoxia response in the developmental or matured retinal tissue may lead congenital vascular anomalies or adult neovascular ocular diseases. To regulate hypoxia response through HIF activity would be an ideal therapeutic target for these vision-threatening eye diseases.

Original language	English
Title of host publication	New Horizons in Neurovascular Coupling
Subtitle of host publication	A Bridge Between Brain Circulation and Neural Plasticity, 2016
Editors	Kazuto Masamoto, Hajime Hirase, Katsuya Yamada
Publisher	Elsevier B.V.
Pages	201-211
Number of pages	11
ISBN (Print)	9780444637048
DOIs	https://doi.org/10.1016/bs.pbr.2016.03.006
Publication status	Published - 2016 Jan 1

Publication series

Name	Progress in Brain Research
Volume	225
ISSN (Print)	0079-6123
ISSN (Electronic)	1875-7855

Keywords

Developmental anomaly
Hypoxia-inducible factor
Neovascular ocular disease
Persistent hyperplastic primary vitreous
Retina
Vascular endothelial growth factor
Von Hippel-Lindau protein

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/bs.pbr.2016.03.006

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Cite this

Kurihara, T. (2016). Development and pathological changes of neurovascular unit regulated by hypoxia response in the retina. In K. Masamoto, H. Hirase, & K. Yamada (Eds.), New Horizons in Neurovascular Coupling: A Bridge Between Brain Circulation and Neural Plasticity, 2016 (pp. 201-211). (Progress in Brain Research; Vol. 225). Elsevier B.V.. https://doi.org/10.1016/bs.pbr.2016.03.006

Development and pathological changes of neurovascular unit regulated by hypoxia response in the retina. / Kurihara, T.

New Horizons in Neurovascular Coupling: A Bridge Between Brain Circulation and Neural Plasticity, 2016. ed. / Kazuto Masamoto; Hajime Hirase; Katsuya Yamada. Elsevier B.V., 2016. p. 201-211 (Progress in Brain Research; Vol. 225).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kurihara, T 2016, Development and pathological changes of neurovascular unit regulated by hypoxia response in the retina. in K Masamoto, H Hirase & K Yamada (eds), New Horizons in Neurovascular Coupling: A Bridge Between Brain Circulation and Neural Plasticity, 2016. Progress in Brain Research, vol. 225, Elsevier B.V., pp. 201-211. https://doi.org/10.1016/bs.pbr.2016.03.006

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