TY - GEN
T1 - Development and pathological changes of neurovascular unit regulated by hypoxia response in the retina
AU - Kurihara, T.
N1 - Funding Information:
I thank Drs. Kazuo Tsubota, Martin Friedlander, Hideyuki Okano, Susumu Ishida, Yoshiaki Kubota, and Yoko Ozawa for their mentorship in the original articles cited in this chapter. T.K. is supported by MEXT/JSPS KAKENHI Grant Number 15K10881, Charitable Trust Fund for Ophthalmic Research in Commemoration of Santen Pharmaceutical's Founder, The Uehara Memorial Foundation, and The Takeda Science Foundation.
PY - 2016
Y1 - 2016
N2 - Retina is a highly vascularized tissue with a high oxygen and metabolic demand receiving light located in the back of the eye. The development and the maintenance of the retinal vasculature are important to regulate the homeostasis in the tissue. α Subunits of hypoxia-inducible factor (HIF) are key molecules in hypoxia response inducing genes required for cell survival such as vascular endothelial growth factor under hypoxia. Neurons, glia, and vascular endothelium cells interdependently form neurovascular unit in the retina tightly regulated by hypoxia response via HIF expression. A corruption of the precise hypoxia response in the developmental or matured retinal tissue may lead congenital vascular anomalies or adult neovascular ocular diseases. To regulate hypoxia response through HIF activity would be an ideal therapeutic target for these vision-threatening eye diseases.
AB - Retina is a highly vascularized tissue with a high oxygen and metabolic demand receiving light located in the back of the eye. The development and the maintenance of the retinal vasculature are important to regulate the homeostasis in the tissue. α Subunits of hypoxia-inducible factor (HIF) are key molecules in hypoxia response inducing genes required for cell survival such as vascular endothelial growth factor under hypoxia. Neurons, glia, and vascular endothelium cells interdependently form neurovascular unit in the retina tightly regulated by hypoxia response via HIF expression. A corruption of the precise hypoxia response in the developmental or matured retinal tissue may lead congenital vascular anomalies or adult neovascular ocular diseases. To regulate hypoxia response through HIF activity would be an ideal therapeutic target for these vision-threatening eye diseases.
KW - Developmental anomaly
KW - Hypoxia-inducible factor
KW - Neovascular ocular disease
KW - Persistent hyperplastic primary vitreous
KW - Retina
KW - Vascular endothelial growth factor
KW - Von Hippel-Lindau protein
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U2 - 10.1016/bs.pbr.2016.03.006
DO - 10.1016/bs.pbr.2016.03.006
M3 - Conference contribution
C2 - 27130417
AN - SCOPUS:84962136080
SN - 9780444637048
T3 - Progress in Brain Research
SP - 201
EP - 211
BT - New Horizons in Neurovascular Coupling
A2 - Masamoto, Kazuto
A2 - Hirase, Hajime
A2 - Yamada, Katsuya
PB - Elsevier B.V.
ER -