Development-dependent expression of cathepsins D and E in various rat tissues, with special reference to the high expression of cathepsin E in fetal liver

Takashi Kageyama, Masae Tatematsu, Masao Ichinose, Naohisa Yahagi, Kazumasa Miki, Akihiko Moriyama, Satoshi Yonezawa

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The levels of cathepsins D and E in various rat tissues during development were determined with the sensitive assay method we have developed. The level of cathepsin D increased gradually in each tissue during fetal development suggesting the gradual maturation of the lysosomal system in a cell. The level of cathepsin E differed significantly between tissues at various developmental stages. The level in liver increased rapidly from 13-day-gestation fetal stage and decreased gradually at later fetal stages. The level in other tissues such as stomach and spleen began to increase at later fetal stages or the infant stage. Cathepsin E was found in fetal hepatocytes and its gene was hypomethylated when the expression of the gene was elevated. The enzyme was found to be present mainly as a proform suggesting that, after working, an active form is rapidly inactivated.

Original languageEnglish
Pages (from-to)517-523
Number of pages7
JournalZoological Science
Issue number4
Publication statusPublished - 1998 Aug


ASJC Scopus subject areas

  • Animal Science and Zoology

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