Development of a fluorescein analogue, TokyoMagenta, as a novel scaffold for fluorescence probes in red region

Takahiro Egawa, Yuichiro Koide, Kenjiro Hanaoka, Toru Komatsu, Takuya CooTeraiper, Tetsuo Nagano

Research output: Contribution to journalArticlepeer-review

116 Citations (Scopus)

Abstract

We present a design strategy for fluorescence probes with a high off/on activation ratio in the red wavelength region, based on a novel fluorescein analogue in which the O atom at the 10 position of the xanthene chromophore is replaced with a Si atom. To demonstrate the usefulness of this strategy, we designed and synthesized a red-fluorescent probe for β-galactosidase, and showed that it works in live HEK293 cells.

Original languageEnglish
Pages (from-to)4162-4164
Number of pages3
JournalChemical Communications
Volume47
Issue number14
DOIs
Publication statusPublished - 2011 Mar 22
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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