Development of a non-invasive transcutaneous blood glucose monitoring method using an ISFET biosensor.

N. Ito; A. Saito; T. Kuriyama; J. Kimura; T. Arai; M. Kikuchi; S. Kayashima; N. Nagata

Development of a non-invasive transcutaneous blood glucose monitoring method using an ISFET biosensor.

N. Ito, A. Saito, T. Kuriyama, J. Kimura, T. Arai, M. Kikuchi, S. Kayashima, N. Nagata

Department of Applied Physics and Physico-Informatics

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A transcutaneous blood glucose monitoring method has been developed by combining an SOS/ISFET (silicone-on-sapphire/ion sensitive field effect transistor) biosensor with an SEF (suction effusion fluid) collecting technique. The SEF collecting cell has a stainless steel mesh at its bottom which is kept in a weak vacuum condition so as to suck up transcutaneous SEF and deposit it in a reservoir above. An ISFET biosensor, consisting of immobilized enzyme membranes, enables the detection of glucose concentrations in very small samples. The method has been successfully applied to non-invasive monitoring of human blood glucose levels during tests involving 75 g OGTT (oral glucose tolerance test). Glucose concentrations measured with SEF showed good correlation with those obtained directly from serum. Results suggest the feasibility of a portable blood monitoring system.

Original language	English
Pages (from-to)	35-45
Number of pages	11
Journal	Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering
Volume	4
Issue number	1
Publication status	Published - 1992

ASJC Scopus subject areas

Biophysics

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Development of a non-invasive transcutaneous blood glucose monitoring method using an ISFET biosensor. / Ito, N.; Saito, A.; Kuriyama, T.; Kimura, J.; Arai, T.; Kikuchi, M.; Kayashima, S.; Nagata, N.

In: Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering, Vol. 4, No. 1, 1992, p. 35-45.

Research output: Contribution to journal › Article › peer-review

Ito, N, Saito, A, Kuriyama, T, Kimura, J, Arai, T, Kikuchi, M, Kayashima, S & Nagata, N 1992, 'Development of a non-invasive transcutaneous blood glucose monitoring method using an ISFET biosensor.', Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering, vol. 4, no. 1, pp. 35-45.

Ito, N. ; Saito, A. ; Kuriyama, T. ; Kimura, J. ; Arai, T. ; Kikuchi, M. ; Kayashima, S. ; Nagata, N. / Development of a non-invasive transcutaneous blood glucose monitoring method using an ISFET biosensor. In: Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering. 1992 ; Vol. 4, No. 1. pp. 35-45.

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