Development of a non-invasive transcutaneous blood glucose monitoring method using an ISFET biosensor.

N. Ito, A. Saito, T. Kuriyama, J. Kimura, Tsunenori Arai, M. Kikuchi, S. Kayashima, N. Nagata

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A transcutaneous blood glucose monitoring method has been developed by combining an SOS/ISFET (silicone-on-sapphire/ion sensitive field effect transistor) biosensor with an SEF (suction effusion fluid) collecting technique. The SEF collecting cell has a stainless steel mesh at its bottom which is kept in a weak vacuum condition so as to suck up transcutaneous SEF and deposit it in a reservoir above. An ISFET biosensor, consisting of immobilized enzyme membranes, enables the detection of glucose concentrations in very small samples. The method has been successfully applied to non-invasive monitoring of human blood glucose levels during tests involving 75 g OGTT (oral glucose tolerance test). Glucose concentrations measured with SEF showed good correlation with those obtained directly from serum. Results suggest the feasibility of a portable blood monitoring system.

Original languageEnglish
Pages (from-to)35-45
Number of pages11
JournalFrontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering
Volume4
Issue number1
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Suction
Biosensing Techniques
Blood Glucose
Glucose
Immobilized Enzymes
Aluminum Oxide
Stainless Steel
Silicones
Glucose Tolerance Test
Vacuum
Ions
Membranes
Serum

ASJC Scopus subject areas

  • Biophysics

Cite this

Development of a non-invasive transcutaneous blood glucose monitoring method using an ISFET biosensor. / Ito, N.; Saito, A.; Kuriyama, T.; Kimura, J.; Arai, Tsunenori; Kikuchi, M.; Kayashima, S.; Nagata, N.

In: Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering, Vol. 4, No. 1, 1992, p. 35-45.

Research output: Contribution to journalArticle

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AU - Kayashima, S.

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