Abstract
A transcutaneous blood glucose monitoring method has been developed by combining an SOS/ISFET (silicone-on-sapphire/ion sensitive field effect transistor) biosensor with an SEF (suction effusion fluid) collecting technique. The SEF collecting cell has a stainless steel mesh at its bottom which is kept in a weak vacuum condition so as to suck up transcutaneous SEF and deposit it in a reservoir above. An ISFET biosensor, consisting of immobilized enzyme membranes, enables the detection of glucose concentrations in very small samples. The method has been successfully applied to non-invasive monitoring of human blood glucose levels during tests involving 75 g OGTT (oral glucose tolerance test). Glucose concentrations measured with SEF showed good correlation with those obtained directly from serum. Results suggest the feasibility of a portable blood monitoring system.
| Original language | English |
|---|---|
| Pages (from-to) | 35-45 |
| Number of pages | 11 |
| Journal | Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering |
| Volume | 4 |
| Issue number | 1 |
| Publication status | Published - 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biophysics
Cite this
Development of a non-invasive transcutaneous blood glucose monitoring method using an ISFET biosensor. / Ito, N.; Saito, A.; Kuriyama, T.; Kimura, J.; Arai, Tsunenori; Kikuchi, M.; Kayashima, S.; Nagata, N.
In: Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering, Vol. 4, No. 1, 1992, p. 35-45.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of a non-invasive transcutaneous blood glucose monitoring method using an ISFET biosensor.
AU - Ito, N.
AU - Saito, A.
AU - Kuriyama, T.
AU - Kimura, J.
AU - Arai, Tsunenori
AU - Kikuchi, M.
AU - Kayashima, S.
AU - Nagata, N.
PY - 1992
Y1 - 1992
N2 - A transcutaneous blood glucose monitoring method has been developed by combining an SOS/ISFET (silicone-on-sapphire/ion sensitive field effect transistor) biosensor with an SEF (suction effusion fluid) collecting technique. The SEF collecting cell has a stainless steel mesh at its bottom which is kept in a weak vacuum condition so as to suck up transcutaneous SEF and deposit it in a reservoir above. An ISFET biosensor, consisting of immobilized enzyme membranes, enables the detection of glucose concentrations in very small samples. The method has been successfully applied to non-invasive monitoring of human blood glucose levels during tests involving 75 g OGTT (oral glucose tolerance test). Glucose concentrations measured with SEF showed good correlation with those obtained directly from serum. Results suggest the feasibility of a portable blood monitoring system.
AB - A transcutaneous blood glucose monitoring method has been developed by combining an SOS/ISFET (silicone-on-sapphire/ion sensitive field effect transistor) biosensor with an SEF (suction effusion fluid) collecting technique. The SEF collecting cell has a stainless steel mesh at its bottom which is kept in a weak vacuum condition so as to suck up transcutaneous SEF and deposit it in a reservoir above. An ISFET biosensor, consisting of immobilized enzyme membranes, enables the detection of glucose concentrations in very small samples. The method has been successfully applied to non-invasive monitoring of human blood glucose levels during tests involving 75 g OGTT (oral glucose tolerance test). Glucose concentrations measured with SEF showed good correlation with those obtained directly from serum. Results suggest the feasibility of a portable blood monitoring system.
UR - http://www.scopus.com/inward/record.url?scp=0026479429&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026479429&partnerID=8YFLogxK
M3 - Article
C2 - 1599882
AN - SCOPUS:0026479429
VL - 4
SP - 35
EP - 45
JO - Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering
JF - Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering
SN - 0921-3775
IS - 1
ER -