Development of a photocurable gelatin-based gelation material for application to periodontal regeneration

Chie Fukaya, Ayaka Ishikawa, Yasuhide Nakayama, Yoshinobu Murayama, Sadao Omata, Yasuo Hosaka, Taneaki Nakagawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Novel photocurable materials, comprised mixed aqueous solutions of photoreactive gelatin - gelatin partially derivatized with eosin - and polyamine, which is a polymer of N,N-dimethylaminopropylacrylamide, were designed. The materials had appropriate viscosity for shape formation at 37 °C.When photoirradiated with a clinically used visible light source, the materials were almost completely converted to hydrogels to fix their shape in the desired form within several tenths of a second. Cells that were seeded on the eosin-gelatin-coated surface showed good proliferation. Negligible cytotoxicity of eosin-gelatinwas confirmed when culturing was performed in the presence of a large amount of eosin-gelatin. The developed photocurable materials could be converted to a hydrogel with desired physical property change by using a convenient curing procedure of photoirradiation at any desired time and in any shape with minimal cytotoxicity, which was appropriate for the application in periodontal tissue regeneration.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalJournal of Photochemistry and Photobiology A: Chemistry
Volume199
Issue number2-3
DOIs
Publication statusPublished - 2008 Sep 25

Fingerprint

gelatins
gelation
Gelation
Gelatin
Eosine Yellowish-(YS)
regeneration
Cytotoxicity
Hydrogels
Tissue regeneration
Hydrogel
Polyamines
curing
fixing
Light sources
Curing
Polymers
light sources
Physical properties
physical properties
Viscosity

Keywords

  • Eosin
  • Hydrogel
  • Periodontal tissue regeneration
  • Photocurable material
  • Photoreactive gelatin

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Physics and Astronomy(all)

Cite this

Development of a photocurable gelatin-based gelation material for application to periodontal regeneration. / Fukaya, Chie; Ishikawa, Ayaka; Nakayama, Yasuhide; Murayama, Yoshinobu; Omata, Sadao; Hosaka, Yasuo; Nakagawa, Taneaki.

In: Journal of Photochemistry and Photobiology A: Chemistry, Vol. 199, No. 2-3, 25.09.2008, p. 255-260.

Research output: Contribution to journalArticle

Fukaya, Chie ; Ishikawa, Ayaka ; Nakayama, Yasuhide ; Murayama, Yoshinobu ; Omata, Sadao ; Hosaka, Yasuo ; Nakagawa, Taneaki. / Development of a photocurable gelatin-based gelation material for application to periodontal regeneration. In: Journal of Photochemistry and Photobiology A: Chemistry. 2008 ; Vol. 199, No. 2-3. pp. 255-260.
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