Development of a photocurable gelatin-based gelation material for application to periodontal regeneration

Chie Fukaya, Ayaka Ishikawa, Yasuhide Nakayama, Yoshinobu Murayama, Sadao Omata, Yasuo Hosaka, Taneaki Nakagawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Novel photocurable materials, comprised mixed aqueous solutions of photoreactive gelatin - gelatin partially derivatized with eosin - and polyamine, which is a polymer of N,N-dimethylaminopropylacrylamide, were designed. The materials had appropriate viscosity for shape formation at 37 °C.When photoirradiated with a clinically used visible light source, the materials were almost completely converted to hydrogels to fix their shape in the desired form within several tenths of a second. Cells that were seeded on the eosin-gelatin-coated surface showed good proliferation. Negligible cytotoxicity of eosin-gelatinwas confirmed when culturing was performed in the presence of a large amount of eosin-gelatin. The developed photocurable materials could be converted to a hydrogel with desired physical property change by using a convenient curing procedure of photoirradiation at any desired time and in any shape with minimal cytotoxicity, which was appropriate for the application in periodontal tissue regeneration.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalJournal of Photochemistry and Photobiology A: Chemistry
Volume199
Issue number2-3
DOIs
Publication statusPublished - 2008 Sep 25

Keywords

  • Eosin
  • Hydrogel
  • Periodontal tissue regeneration
  • Photocurable material
  • Photoreactive gelatin

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Physics and Astronomy(all)

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