Development of a Portable Measurement System for Automatic Transcutaneous Blood-Glucose Monitoring (II) - Evaluation on Normal and Impaired Glucose Tolerance Human Subjects -

Akio Kaneyoshi, Shinsuke Kayashima, Shio Murakami, Tokitsugu Nishida, Hironobu Iwasaki, Tsunenori Arai, Makoto Kikuchi

Research output: Contribution to journalArticle

Abstract

We have developed a portable measurement system for automatic transcutaneous blood-glucose monitoring by adopting the suction effusion fluid (SEF) from human skin as a sample. We applied our newly developed system to the glucose measurement on human subjects. The SEF can be obtainable transcutaneously by sucking human skin of which a corneous layer was stripped. The glucose concentration of SEF has shown good correlation to blood serum. Since the effusion rate of SEF was 515 μl/cm2/h, the miniature ion sensitive field effect transistor (ISFET) glucose sensor which could repeatedly measure glucose concentration of small volume sample was employed to measure the glucose concentration in the SEF. Our system consists of a main frame (1100 g in weight) and a suction apparatus (120 g in weight). These apparatus were easily fixed on waist and arm with belts. The unique component devices such as a glucose sensor apparatus and pumps were originally developed to realize the portable automatic glucose measurement system. Our system had been applied to rabbit model to evaluate accuracy of the system. The results had shown that there were good correlation between measurement value of our system and conventional method. We applied this system to human subjects. The glucose concentration in the SEF was automatically measured every 30 minutes for 3 hours. The glucose concentration in the SEF from a different portion of human skin was measured by the conventional method. Blood glucose concentration was also measured. The glucose concentration from our system and the conventional method showed almost the same time-history with ±10% correlation error and 0.916 of correlation coefficient. Since we demonstrated excellent performance of our portable system, this system would be great contribution to human glucose monitoring.

Original languageEnglish
Pages (from-to)72-73
Number of pages2
JournalJapanese journal of medical electronics and biological engineering
Volume34
Issue number4
Publication statusPublished - 1996 Dec 1

ASJC Scopus subject areas

  • Biomedical Engineering

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