Development of a potassium ion-selective fluorescent sensor based on 3-styrylated BODIPY

Tomoya Hirata, Takuya Terai, Toru Komatsu, Kenjiro Hanaoka, Tetsuo Nagano

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

We have developed a red-emitting fluorescent K + probe, B3TAC, which also shows a wavelength shift upon binding to K +. The probe was synthesized by conjugating a cryptand-based chelator, 2-triazacryptand [2,2,3-1-(2-methoxyethoxy)benzene (TAC), to position 3 of the BODIPY fluorophore through a styryl linker. In water-acetonitrile mixed solvent, it responded to K + in the physiological concentration range with high selectivity over Na + and other metal ions. B3TAC is potentially useful for measuring cellular K + ion concentration, as well as for simple, naked-eye detection of K + in solution.

Original languageEnglish
Pages (from-to)6090-6093
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number20
DOIs
Publication statusPublished - 2011 Oct 15
Externally publishedYes

Keywords

  • BODIPY
  • Fluorescent probe
  • Potassium ion

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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