Development of a small-molecule-based activatable photoacoustic probe

Takayuki Ikeno, Kenjiro Hanaoka, Yasuteru Urano

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Photoacoustic (PA) imaging is an emerging imaging modality that combines the advantages of optical imaging and ultrasound imaging. In particular, activatable PA probes, which visualize the presence or the activity of target molecules in terms of a change of the PA signal, are useful tools for functional imaging. In this chapter, we describe the development of small-molecule-based activatable PA probes, focusing on the design and synthesis of PA-MMSiNQ, our recently developed activatable PA probe for HOCl. We also describe the protocols used for evaluation of PA-MMSiNQ with a UV–vis spectrometer and a PA imaging microscope.

Original languageEnglish
Title of host publicationPhotoacoustic Probes for In Vivo Imaging
EditorsJefferson Chan
PublisherAcademic Press Inc.
Pages1-19
Number of pages19
ISBN (Print)9780323855303
DOIs
Publication statusPublished - 2021 Jan
Externally publishedYes

Publication series

NameMethods in Enzymology
Volume657
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988

Keywords

  • Activatable PA probes
  • Bioimaging
  • Chemical probes
  • Dark quenchers
  • Near-infrared dyes
  • Photoacoustic imaging
  • Si-rhodamines

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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