Development of allergic bronchopulmonary aspergillosis in a patient with Crohn's disease

Hisashi Sasaki; Jun Miyata; Yohei Maki; Yoshifumi Kimizuka; Nobuyoshi Hayashi; Yuji Fujikura; Akihiko Kawana

doi:10.2169/internalmedicine.2785-19

Development of allergic bronchopulmonary aspergillosis in a patient with Crohn's disease

Hisashi Sasaki, Jun Miyata, Yohei Maki, Yoshifumi Kimizuka, Nobuyoshi Hayashi, Yuji Fujikura, Akihiko Kawana

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is an eosinophilic inflammatory condition characterized by exaggerated immune responses to the fungal genus Aspergillus. Pulmonary manifestations in patients with Crohn's disease (CD) are frequent comorbidities. A 66-year-old man with CD treated with an anti-tumor necrosis factor-α antibody presented with dyspnea. Laboratory findings of elevated blood eosinophils and total serum IgE and positive aspergillus-specific antibodies as well as imaging findings of central bronchiectasis and mucoid impaction indicated a diagnosis of ABPA. To our knowledge, this is the first report of ABPA arising in a patient with CD. We discuss the pathophysiological mechanism of this rare complication.

Original language	English
Pages (from-to)	2835-2838
Number of pages	4
Journal	Internal Medicine
Volume	58
Issue number	19
DOIs	https://doi.org/10.2169/internalmedicine.2785-19
Publication status	Published - 2019
Externally published	Yes

Keywords

Anti-tumor necrosis factor-α antibody
Aspergillus
Asthma
Inflammatory bowel disease
Pulmonary disorder

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.2785-19

Cite this

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title = "Development of allergic bronchopulmonary aspergillosis in a patient with Crohn's disease",

abstract = "Allergic bronchopulmonary aspergillosis (ABPA) is an eosinophilic inflammatory condition characterized by exaggerated immune responses to the fungal genus Aspergillus. Pulmonary manifestations in patients with Crohn's disease (CD) are frequent comorbidities. A 66-year-old man with CD treated with an anti-tumor necrosis factor-α antibody presented with dyspnea. Laboratory findings of elevated blood eosinophils and total serum IgE and positive aspergillus-specific antibodies as well as imaging findings of central bronchiectasis and mucoid impaction indicated a diagnosis of ABPA. To our knowledge, this is the first report of ABPA arising in a patient with CD. We discuss the pathophysiological mechanism of this rare complication.",

keywords = "Anti-tumor necrosis factor-α antibody, Aspergillus, Asthma, Inflammatory bowel disease, Pulmonary disorder",

author = "Hisashi Sasaki and Jun Miyata and Yohei Maki and Yoshifumi Kimizuka and Nobuyoshi Hayashi and Yuji Fujikura and Akihiko Kawana",

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language = "English",

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TY - JOUR

T1 - Development of allergic bronchopulmonary aspergillosis in a patient with Crohn's disease

AU - Sasaki, Hisashi

AU - Miyata, Jun

AU - Maki, Yohei

AU - Kimizuka, Yoshifumi

AU - Hayashi, Nobuyoshi

AU - Fujikura, Yuji

AU - Kawana, Akihiko

PY - 2019

Y1 - 2019

N2 - Allergic bronchopulmonary aspergillosis (ABPA) is an eosinophilic inflammatory condition characterized by exaggerated immune responses to the fungal genus Aspergillus. Pulmonary manifestations in patients with Crohn's disease (CD) are frequent comorbidities. A 66-year-old man with CD treated with an anti-tumor necrosis factor-α antibody presented with dyspnea. Laboratory findings of elevated blood eosinophils and total serum IgE and positive aspergillus-specific antibodies as well as imaging findings of central bronchiectasis and mucoid impaction indicated a diagnosis of ABPA. To our knowledge, this is the first report of ABPA arising in a patient with CD. We discuss the pathophysiological mechanism of this rare complication.

AB - Allergic bronchopulmonary aspergillosis (ABPA) is an eosinophilic inflammatory condition characterized by exaggerated immune responses to the fungal genus Aspergillus. Pulmonary manifestations in patients with Crohn's disease (CD) are frequent comorbidities. A 66-year-old man with CD treated with an anti-tumor necrosis factor-α antibody presented with dyspnea. Laboratory findings of elevated blood eosinophils and total serum IgE and positive aspergillus-specific antibodies as well as imaging findings of central bronchiectasis and mucoid impaction indicated a diagnosis of ABPA. To our knowledge, this is the first report of ABPA arising in a patient with CD. We discuss the pathophysiological mechanism of this rare complication.

KW - Anti-tumor necrosis factor-α antibody

KW - Aspergillus

KW - Asthma

KW - Inflammatory bowel disease

KW - Pulmonary disorder

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Development of allergic bronchopulmonary aspergillosis in a patient with Crohn's disease

Abstract

Keywords

ASJC Scopus subject areas

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