TY - JOUR
T1 - Development of chromogenic reactands for optical sensing of alcohols
AU - Mohr, Gerhard J.
AU - Citterio, Daniel
AU - Spichiger-Keller, Ursula E.
N1 - Funding Information:
This work was supported by the Austrian Science Foundation within Erwin-Schroedinger fellowship J01260-CHE which is gratefully acknowledged. We would also like to thank Drs. Luzi Jenny and Ines Oehme for the support during synthesis. Gerhard J. Mohr received his Ph.D. in chemistry (1996) at the Karl-Franzens University, Graz. His thesis focused on the development of optical sensors, in particular for anions. During the thesis he has carried out research in the groups of Professors P.R. Coulet (Lyon) and U.-W. Grummt (Jena) to work on biosensors and near-infrared dyes. In 1996 he has moved to the Centre for Chemical Sensors of ETH Zurich and is currently developing a new concept for optical sensors based on chromogenic and fluorogenic reactands. Daniel Citterio graduated in chemistry in 1992 (ETH Zurich) with special emphasis on organic and analytical chemistry. His diploma work was entitled ‘Magnesium-selective measurements under physiological conditions’. In 1998, he has received his Ph.D. at the Centre for Chemical Sensors of ETH Zurich in the field of NIR-dyes for optical sensing. Ursula E. Spichiger-Keller is the head of the Centre for Chemical Sensors/Biosensors and bioAnalytical Chemistry of the Swiss Federal Institute of Technology (ETH) in Zurich which is funded entirely through national grants, private funds and cooperations with industrial partners. She performed permanent collaboration with Prof. Wilhelm Simon since 1988 and her habilitation work entitled ‘Chemical sensors and biosensors for medical and biological applications: a developing field in analytical chemistry’ was handed to the Department of Pharmacy at ETH Zurich in January 1994; as from September 1995 the ‘Venia legendi’ at ETH Zurich was granted.
PY - 1998
Y1 - 1998
N2 - A new class of chromogenic reactands (or `chromoreactands') has been synthesized that reversibly interact with alcohols resulting in a change in absorbance. When embedded in plasticized PVC membranes, 4-(N,N-dioctylamino)-4′-trifluoroacetyl-azobenzene (ETHT 4001) shows a significant signal change on exposure to aqueous ethanol solution with a decrease in absorbance at around 490 nm and an increase in absorbance at around 430 nm wavelength. The sensor layer exhibits a dynamic range from 2 to 50 vol% ethanol with highest sensitivity in the 5-35 vol% range. The unit of detection is 1.5 vol%. The absorbance of the sensor membrane is virtually insensitive to changes in pH, however, the magnitude of the relative signal change between plain buffer and buffer containing ethanol is pH dependent. A similar response is observed for 1-(N,N-dioctylamino)-4-(4-trifluoroacetylphenylazo)-naphthalene (ET 4002), however, with the absorbance shifted to longer wavelengths. The behaviour of the reactands dissolved in alcohols correlates with the selectivity of the dyes in the sensor membranes.
AB - A new class of chromogenic reactands (or `chromoreactands') has been synthesized that reversibly interact with alcohols resulting in a change in absorbance. When embedded in plasticized PVC membranes, 4-(N,N-dioctylamino)-4′-trifluoroacetyl-azobenzene (ETHT 4001) shows a significant signal change on exposure to aqueous ethanol solution with a decrease in absorbance at around 490 nm and an increase in absorbance at around 430 nm wavelength. The sensor layer exhibits a dynamic range from 2 to 50 vol% ethanol with highest sensitivity in the 5-35 vol% range. The unit of detection is 1.5 vol%. The absorbance of the sensor membrane is virtually insensitive to changes in pH, however, the magnitude of the relative signal change between plain buffer and buffer containing ethanol is pH dependent. A similar response is observed for 1-(N,N-dioctylamino)-4-(4-trifluoroacetylphenylazo)-naphthalene (ET 4002), however, with the absorbance shifted to longer wavelengths. The behaviour of the reactands dissolved in alcohols correlates with the selectivity of the dyes in the sensor membranes.
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U2 - 10.1016/s0925-4005(98)00132-4
DO - 10.1016/s0925-4005(98)00132-4
M3 - Article
AN - SCOPUS:0032121072
SN - 0925-4005
VL - 49 B49
SP - 226
EP - 234
JO - Sensors and Actuators B: Chemical
JF - Sensors and Actuators B: Chemical
IS - 3
ER -