Development of diversity-enhanced extracts of curcuma zedoaria and their new sesquiterpene-like compounds

Haruhisa Kikuchi; Kazuyoshi Sakurai; Yoshiteru Oshima

doi:10.1021/ol5004324

Development of diversity-enhanced extracts of curcuma zedoaria and their new sesquiterpene-like compounds

Haruhisa Kikuchi, Kazuyoshi Sakurai, Yoshiteru Oshima

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Through the combination of natural products chemistry and diversity-oriented synthesis, a new approach, diversity-enhanced extracts, for increasing the diversity of natural product-like compounds is proposed. They are prepared from chemical reactions that remodel molecular scaffolds directly on extracts of natural resources. This method was applied to terpenes extracted from Curcuma zedoaria. Epoxidation and subsequent ring-opening reactions of epoxides were used to modify molecular skeletons. As a result, seven sesquiterpene-like compounds with some containing new molecular skeletons were obtained.

Original language	English
Pages (from-to)	1916-1919
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	7
DOIs	https://doi.org/10.1021/ol5004324
Publication status	Published - 2014 Apr 4
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol5004324

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Development of diversity-enhanced extracts of curcuma zedoaria and their new sesquiterpene-like compounds

Abstract

ASJC Scopus subject areas

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