Development of immunotherapy for cancer: lessons from melanoma research

Yutaka Kawakami

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Identification of human melanoma antigens by various molecular biological and immunological techniques and evaluation of tumor reactive T cells in patients with the identified tumor antigen and HLA tetramer technology, not only provided us more profound understanding of anti-tumor immune responses in human, but also led to reveal basic problems in each step towards immunological tumor rejection, including systemic suppressive mechanisms such as regulatory T cell induction and local inhibitory environment in tumors. Based on these results obtained from the basic and clinical researches, various improvements have been applied for immunotherapy, including active immunization with modified antigenic peptides and recombinant virus, T cell adoptive transfer with lymphodepletive pretreatment, and administration of anti-CTLA-4 Ab, although further improvement is necessary. The translational research performed on melanoma, would facilitate development of immunotherapy for other cancers.

Original languageEnglish
Pages (from-to)87-98
Number of pages12
JournalNihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology
Volume27
Issue number2
Publication statusPublished - 2004

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Immunotherapy
Melanoma
Research
Neoplasms
Immunologic Techniques
Melanoma-Specific Antigens
T-Lymphocytes
Forensic Anthropology
Translational Medical Research
Adoptive Transfer
Neoplasm Antigens
Regulatory T-Lymphocytes
Vaccination
Viruses
Technology
Peptides

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Development of immunotherapy for cancer : lessons from melanoma research. / Kawakami, Yutaka.

In: Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology, Vol. 27, No. 2, 2004, p. 87-98.

Research output: Contribution to journalArticle

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