Development of Inhibitors of Salicylic Acid Signaling

Kai Jiang, Tetsuya Kurimoto, Eun Kyung Seo, Sho Miyazaki, Masatoshi Nakajima, Hidemitsu Nakamura, Tadao Asami

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Salicylic acid (SA) plays important roles in the induction of systemic acquired resistance (SAR) in plants. Determining the mechanism of SAR will extend our understanding of plant defenses against pathogens. We recently reported that PAMD is an inhibitor of SA signaling, which suppresses the expression of the pathogenesis-related PR genes and is expected to facilitate the understanding of SA signaling. However, PAMD strongly inhibits plant growth. To minimize the side effects of PAMD, we synthesized a number of PAMD derivatives, and identified compound 4 that strongly suppresses the expression of the PR genes with fewer adverse effects on plant growth than PAMD. We further showed that the adverse effects on plant growth were partially caused the stabilization of DELLA, which is also related to the pathogen responses. These results indicate that compound 4 would facilitate our understanding of SA signaling and its cross talk with other plant hormones.

Original languageEnglish
Pages (from-to)7124-7133
Number of pages10
JournalJournal of Agricultural and Food Chemistry
Volume63
Issue number32
DOIs
Publication statusPublished - 2015 Aug 19
Externally publishedYes

Fingerprint

Salicylic Acid
salicylic acid
systemic acquired resistance
adverse effects
plant growth
Pathogens
Genes
Growth
Plant Growth Regulators
pathogens
plant hormones
genes
pathogenesis
Stabilization
Derivatives
Gene Expression

Keywords

  • chemical inhibitor
  • salicylic acid
  • signaling pathway
  • systemic acquired resistance

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

Cite this

Jiang, K., Kurimoto, T., Seo, E. K., Miyazaki, S., Nakajima, M., Nakamura, H., & Asami, T. (2015). Development of Inhibitors of Salicylic Acid Signaling. Journal of Agricultural and Food Chemistry, 63(32), 7124-7133. https://doi.org/10.1021/acs.jafc.5b01521

Development of Inhibitors of Salicylic Acid Signaling. / Jiang, Kai; Kurimoto, Tetsuya; Seo, Eun Kyung; Miyazaki, Sho; Nakajima, Masatoshi; Nakamura, Hidemitsu; Asami, Tadao.

In: Journal of Agricultural and Food Chemistry, Vol. 63, No. 32, 19.08.2015, p. 7124-7133.

Research output: Contribution to journalArticle

Jiang, K, Kurimoto, T, Seo, EK, Miyazaki, S, Nakajima, M, Nakamura, H & Asami, T 2015, 'Development of Inhibitors of Salicylic Acid Signaling', Journal of Agricultural and Food Chemistry, vol. 63, no. 32, pp. 7124-7133. https://doi.org/10.1021/acs.jafc.5b01521
Jiang K, Kurimoto T, Seo EK, Miyazaki S, Nakajima M, Nakamura H et al. Development of Inhibitors of Salicylic Acid Signaling. Journal of Agricultural and Food Chemistry. 2015 Aug 19;63(32):7124-7133. https://doi.org/10.1021/acs.jafc.5b01521
Jiang, Kai ; Kurimoto, Tetsuya ; Seo, Eun Kyung ; Miyazaki, Sho ; Nakajima, Masatoshi ; Nakamura, Hidemitsu ; Asami, Tadao. / Development of Inhibitors of Salicylic Acid Signaling. In: Journal of Agricultural and Food Chemistry. 2015 ; Vol. 63, No. 32. pp. 7124-7133.
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