Development of lecithinized superoxide dismutase

Tohru Mizushima

Research output: Contribution to journalArticlepeer-review

Abstract

Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are considered to involve lung injury induced by reactive oxygen species (ROS), in particular superoxide anion. The enzyme, superoxide dismutase (SOD) catalyses the dismutation of superoxide anion to hydrogen peroxide. Lecithinized SOD (PC-SOD) has overcome a number of previous clinical limitations of SOD, including low tissue affinity and low stability in plasma. Recent animal studies suggest that PC-SOD is effective for the treatment of IPF and COPD. We are now performing a clinical study of PC-SOD for IPF patients.

Original languageEnglish
Pages (from-to)1094-1103
Number of pages10
JournalJapanese Journal of Chest Diseases
Volume72
Issue number10
Publication statusPublished - 2013 Oct 31

Keywords

  • Chronic obstructive pulmonary disease
  • Idiopathic pulmonary fibrosis
  • Lecithinized SOD
  • Reactive oxygen species
  • Superoxide dismutase

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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